SCHEMBL299549

SCHEMBL299549

N#Cc1ccc(C(=O)Nc2c(Cl)cc(C(F)(C(F)(F)F)C(F)(F)C(F)(F)F)cc2Br)cc1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 2/20 0.43
RXFP1 Q9HBX9 1/20 0.39
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
NPC1 O15118 2/20 0.37
RAB9A P51151 2/20 0.37
PDK1 Q15118 1/20 0.37
PDK2 Q15119 1/20 0.37
PDK3 Q15120 1/20 0.37
PDK4 Q16654 1/20 0.37
ESR1 P03372 1/20 0.37
ALDH1A1 P00352 2/20 0.37
LMNA P02545 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
MAPT P10636 1/20 0.36
PKM P14618 1/20 0.36
HSD11B1 P28845 4/20 0.35
MRGPRX4 Q96LA9 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL298955 0.86 ALDH1A1 (0.43) MEN1KMT2AALDH1A1LMNASMN1; SMN2
SCHEMBL299222 0.85 MLYCD (0.41) MLYCDRXFP1MEN1KMT2ANPC1
SCHEMBL3695537 0.85 KCNQ3 (0.35) MEN1KMT2AALDH1A1LMNASMN1; SMN2
SCHEMBL299030 0.85 KMT2A (0.48) MLYCDRXFP1MEN1KMT2ANPC1
SCHEMBL1766884 0.84 RXFP1 (0.49) MLYCDRXFP1MEN1KMT2ANPC1
SCHEMBL3699644 0.83 KMT2A (0.36) RXFP1MEN1KMT2APDK1PDK2
SCHEMBL29362173 0.83 KMT2A (0.36) RXFP1MEN1KMT2APDK1PDK2
SCHEMBL299618 0.82 MAPT (0.45) MEN1KMT2AALDH1A1LMNASMN1; SMN2
SCHEMBL1767265 0.81 RXFP1 (0.51) MLYCDRXFP1KMT2APKM
SCHEMBL3698447 0.80 LRRK2 (0.34) KMT2APDK1PDK2PDK3PDK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2427427-A1 4 -CYANO- 3 -BENZOYLAMINO-N- PHENYL-BENZAMIDES FOR USE IN PEST CONTROL Syngenta Participations AG (CH) 2012-03-14 EP disclosed