Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 3/20 | 0.34 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13136410 | 0.77 | CFTR (0.48) | AKR1C1HSP90AA1MAPTALDH1A1PRMT1 | |
| SCHEMBL31073015 | 0.75 | OPRM1 (0.47) | OPRM1OPRD1CA1CA2CA4 | |
| SCHEMBL16064982 | 0.74 | OPRM1 (0.46) | OPRM1OPRD1CA1CA2CA4 | |
| SCHEMBL29618364 | 0.71 | PDK2 (0.53) | OPRM1OPRD1CA1CA2CA4 | |
| SCHEMBL29618362 | 0.71 | PDK2 (0.53) | OPRM1OPRD1CA1CA2CA4 | |
| SCHEMBL24517455 | 0.71 | PDK2 (0.53) | OPRM1OPRD1CA1CA2CA4 | |
| SCHEMBL25866294 | 0.70 | OPRM1 (0.43) | OPRM1OPRD1CA1CA2CA4 | |
| SCHEMBL18373219 | 0.69 | OPRM1 (0.42) | OPRM1OPRD1CA1CA2CA4 | |
| SCHEMBL15820469 | 0.69 | PDK2 (0.44) | CA1CA2CA4CA7CA9 | |
| SCHEMBL14422532 | 0.68 | SMN1; SMN2 (0.45) | AKR1C1MAPTALDH1A1PRMT1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022188735-A1 | HETEROCYCLIC COMPOUNDS AS HPK1 INHIBITORS | GUANGDONG NEWOPP BIOPHARMACEUTICALS CO., LTD. (CN) | 2022-09-15 | — | — | WO | disclosed |