Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.45 |
| ▸ | JAK2 | O60674 | 11/20 | 0.45 |
| ▸ | JAK1 | P23458 | 11/20 | 0.45 |
| ▸ | TYK2 | P29597 | 8/20 | 0.45 |
| ▸ | WEE1 | P30291 | 3/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922918 | 0.88 | JAK2 (0.44) | JAK3JAK2JAK1TYK2WEE1 | |
| Hydrochloric Acid SCHEMBL29922825 | 0.83 | JAK1 (0.50) | JAK3JAK2JAK1TYK2SYK | |
| SCHEMBL28358941 | 0.82 | TYK2 (0.68) | JAK3JAK2JAK1TYK2WEE1 | |
| Hydrochloric Acid SCHEMBL29922656 | 0.82 | JAK2 (0.42) | JAK3JAK2JAK1TYK2SYK | |
| SCHEMBL29923095 | 0.81 | JAK2 (0.66) | JAK3JAK2JAK1TYK2MAPK8 | |
| SCHEMBL29552531 | 0.80 | JAK2 (0.43) | JAK3JAK2JAK1TYK2WEE1 | |
| SCHEMBL28362691 | 0.76 | TYK2 (0.70) | JAK3JAK2JAK1TYK2WEE1 | |
| SCHEMBL29922714 | 0.75 | JAK2 (0.47) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL29551775 | 0.75 | TYK2 (0.55) | JAK3JAK2JAK1TYK2WEE1 | |
| SCHEMBL29922596 | 0.74 | JAK2 (0.61) | JAK3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |