Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.44 |
| ▸ | JAK1 | P23458 | 5/20 | 0.44 |
| ▸ | TYK2 | P29597 | 5/20 | 0.44 |
| ▸ | JAK3 | P52333 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CDK11A | Q9UQ88 | 3/20 | 0.37 |
| ▸ | WEE1 | P30291 | 3/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.36 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | CCND1 | P24385 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922528 | 0.88 | JAK3 (0.45) | JAK2JAK1TYK2JAK3CDK11A | |
| SCHEMBL29923095 | 0.81 | JAK2 (0.66) | JAK2JAK1TYK2JAK3SLC2A1 | |
| SCHEMBL28359206 | 0.81 | JAK2 (0.68) | JAK2JAK1TYK2JAK3L3MBTL1 | |
| SCHEMBL29922596 | 0.78 | JAK2 (0.61) | JAK2JAK1TYK2JAK3CSF1R | |
| SCHEMBL29922756 | 0.76 | JAK2 (0.40) | JAK2JAK1TYK2JAK3CDK11A | |
| SCHEMBL29551761 | 0.75 | TYK2 (0.57) | JAK2JAK1TYK2JAK3L3MBTL1 | |
| SCHEMBL29922714 | 0.75 | JAK2 (0.47) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL28359224 | 0.74 | TYK2 (0.56) | JAK2JAK1TYK2JAK3L3MBTL1 | |
| SCHEMBL29922837 | 0.74 | TYK2 (0.56) | JAK2JAK1TYK2JAK3L3MBTL1 | |
| SCHEMBL29922888 | 0.73 | MKNK1 (0.37) | JAK2JAK1TYK2JAK3ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |