Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 10/20 | 0.51 |
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
| ▸ | JAK1 | P23458 | 4/20 | 0.47 |
| ▸ | JAK3 | P52333 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922801 | 0.80 | RAB9A (0.54) | TYK2JAK2JAK1JAK3MAPT | |
| SCHEMBL28362776 | 0.80 | TYK2 (0.66) | TYK2JAK2JAK1JAK3MAPT | |
| SCHEMBL29923095 | 0.80 | JAK2 (0.66) | TYK2JAK2JAK1JAK3STAT6 | |
| SCHEMBL29922889 | 0.76 | JAK2 (0.52) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL29922923 | 0.76 | JAK2 (0.40) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL29922887 | 0.76 | JAK1 (0.40) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL29922737 | 0.75 | TYK2 (0.67) | TYK2JAK2JAK1JAK3STAT6 | |
| SCHEMBL29922762 | 0.73 | JAK2 (0.46) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL29922608 | 0.73 | JAK2 (0.39) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL29922684 | 0.73 | TYK2 (0.40) | TYK2JAK2JAK1JAK3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |