Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359009 | 1.00 | SYK (0.46) | SYKMAPTALOX15HPGDSMN1; SMN2 | |
| SCHEMBL29552492 | 0.85 | SYK (0.46) | SYKMAPTPOLBKMT2AMEN1 | |
| SCHEMBL15091096 | 0.85 | SYK (0.56) | SYKMAPTHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL29922807 | 0.83 | SYK (0.40) | SYKMAPTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL29922643 | 0.82 | ALDH1A1 (0.47) | SYKMAPTSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL28359257 | 0.82 | ALDH1A1 (0.47) | SYKMAPTSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL28359050 | 0.82 | SYK (0.46) | SYKALDH1A1KDM4ERAB9A | |
| SCHEMBL28359017 | 0.82 | SYK (0.46) | SYKMAPTALOX15HPGDSMN1; SMN2 | |
| SCHEMBL29922768 | 0.82 | SYK (0.46) | SYKALDH1A1KDM4ERAB9A | |
| SCHEMBL29922724 | 0.82 | SYK (0.46) | SYKMAPTALOX15HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |