Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 9/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922643 | 1.00 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MAPTPOLBKDM4E | |
| SCHEMBL29551896 | 0.89 | EHMT2 (0.47) | ALDH1A1SMN1; SMN2MAPTPOLBKDM4E | |
| SCHEMBL15091096 | 0.83 | SYK (0.56) | ALDH1A1SMN1; SMN2MAPTKDM4ENPC1 | |
| SCHEMBL28359009 | 0.82 | SYK (0.46) | ALDH1A1SMN1; SMN2MAPTPOLBKDM4E | |
| SCHEMBL29922937 | 0.82 | SYK (0.46) | ALDH1A1SMN1; SMN2MAPTPOLBKDM4E | |
| SCHEMBL22165533 | 0.82 | KMT2A (0.46) | ALDH1A1SMN1; SMN2MAPTKDM4ENPC1 | |
| SCHEMBL29922768 | 0.80 | SYK (0.46) | ALDH1A1KDM4ENPC1SYKRAB9A | |
| SCHEMBL29922724 | 0.80 | SYK (0.46) | ALDH1A1SMN1; SMN2MAPTPOLBKDM4E | |
| SCHEMBL28359017 | 0.80 | SYK (0.46) | ALDH1A1SMN1; SMN2MAPTPOLBKDM4E | |
| SCHEMBL28359050 | 0.80 | SYK (0.46) | ALDH1A1KDM4ENPC1SYKRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |