Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | PARP1 | P09874 | 3/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.32 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.32 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.32 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.32 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.32 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | HTR5A | P47898 | 1/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24916486 | 1.00 | PTGDR2 (0.34) | PTGDR2NOTUMMAPK14PARP1NCOA1 | |
| SCHEMBL29923807 | 0.89 | CDK2 (0.38) | PARP1NCOA1NCOA3PARP10PARP11 | |
| SCHEMBL27167349 | 0.80 | NOTUM (0.34) | NOTUMMAPK14CASP3DRD2DRD4 | |
| SCHEMBL22990372 | 0.74 | PARP10 (0.47) | NOTUMPARP1PARP10PARP11 | |
| SCHEMBL14151101 | 0.73 | NOTUM (0.43) | NOTUM | |
| SCHEMBL730816 | 0.73 | NOTUM (0.48) | NOTUM | |
| SCHEMBL14448997 | 0.71 | NOTUM (0.47) | NOTUM | |
| SCHEMBL25977472 | 0.71 | THRB (0.46) | NOTUMHTT | |
| SCHEMBL30190488 | 0.70 | WDR5 (0.44) | — | |
| SCHEMBL29923978 | 0.70 | WDR5 (0.42) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4055013-A1 | WDR5 INHIBITORS AND MODULATORS | Vanderbilt University (US) | 2022-09-14 | — | — | EP | disclosed |