Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | PRKCI | P41743 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 2/20 | 0.38 |
| ▸ | GRM6 | O15303 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1292847 | 1.00 | NAPRT (0.56) | NAPRTPRKCIKDM4EALDH1A1POLB | |
| SCHEMBL22978782 | 0.88 | NAPRT (0.50) | NAPRTPRKCIKDM4EALDH1A1POLB | |
| SCHEMBL2633213 | 0.81 | P2RX7 (0.56) | NAPRTKDM4EALDH1A1POLBADRA1A | |
| SCHEMBL30441012 | 0.81 | KDM4E (0.46) | KDM4EALDH1A1POLBADRA1AADRA1B | |
| SCHEMBL163493 | 0.81 | POLB (0.45) | NAPRTKDM4EALDH1A1POLBADRA1A | |
| SCHEMBL29412876 | 0.81 | NAPRT (0.61) | NAPRTPRKCIKDM4EALDH1A1POLB | |
| SCHEMBL167456 | 0.81 | NAPRT (0.61) | NAPRTPRKCIKDM4EALDH1A1POLB | |
| SCHEMBL30665207 | 0.81 | ALDH1A1 (0.42) | NAPRTKDM4EALDH1A1POLBADRA1A | |
| SCHEMBL30665208 | 0.81 | ALDH1A1 (0.42) | NAPRTKDM4EALDH1A1POLBADRA1A | |
| SCHEMBL219458 | 0.80 | NAPRT (0.66) | NAPRTPRKCIKDM4EALDH1A1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220298152-A1 | BACE1 INHIBITORS | HOFFMANN LA ROCHE (US) | 2022-09-22 | — | — | US | disclosed |
| US-11447478-B2 | BACE1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2022-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447478-B2 | BACE1 inhibitors | BACE1, BACE2, APP | NAPRT 998/4885PRKCI 3832/4885KDM4E 3214/4885 |
| US-20220298152-A1 | BACE1 INHIBITORS | BACE1, BACE2, APP | NAPRT 1023/4885PRKCI 3844/4885KDM4E 3137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.