Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 7/20 | 0.43 |
| ▸ | TRHR | P34981 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29555036 | 0.96 | ACE (0.41) | ACETRHRMEN1KMT2AACE2 | |
| SCHEMBL29630560 | 0.92 | OPRK1 (0.46) | ACETRHRMEN1KMT2AOPRK1 | |
| SCHEMBL29590547 | 0.92 | OPRK1 (0.46) | ACETRHRMEN1KMT2AOPRK1 | |
| SCHEMBL29630596 | 0.91 | MEN1 (0.43) | ACETRHRMEN1KMT2AOPRK1 | |
| SCHEMBL29630457 | 0.90 | MC4R (0.42) | TRHRMC4RREN | |
| SCHEMBL29630670 | 0.90 | TRHR (0.42) | ACETRHRACE2OPRK1 | |
| SCHEMBL30385689 | 0.89 | REN (0.47) | TRHRREN | |
| SCHEMBL29630369 | 0.88 | TRHR (0.41) | ACETRHRACE2 | |
| SCHEMBL29630526 | 0.88 | TRHR (0.41) | ACETRHRACE2 | |
| SCHEMBL29590456 | 0.88 | TRHR (0.41) | ACETRHRACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250051408-A1 | FACTOR H VARIANTS FOR TREATMENT OF DISEASE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2025-02-13 | — | — | US | disclosed |
| US-12180254-B1 | Factor H variants for treatment of disease | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2024-12-31 | — | — | US | disclosed |
| CN-115976105-A | Compositions and methods for treating complement-mediated diseases | 宾夕法尼亚州大学信托人 | 2023-04-18 | — | — | CN | disclosed |
| CN-108291216-B | Compositions and methods for treating complement-mediated diseases | 宾夕法尼亚州大学信托人 | 2022-09-16 | — | — | CN | disclosed |