Casticin

Casticin

SCHEMBL29926095

COc1ccc(-c2oc3cc(OC)c(OC)c(O)c3c(=O)c2OC)cc1O

nearest known ligand 0.86

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A P04350 6/20 0.86
TUBB P07437 6/20 0.86
TUBA3C P0DPH7 6/20 0.86
TUBA1B P68363 6/20 0.86
TUBA4A P68366 6/20 0.86
TUBB4B P68371 6/20 0.86
TUBB3 Q13509 6/20 0.86
TUBB2A Q13885 6/20 0.86
TUBB8 Q3ZCM7 6/20 0.86
TUBA3E Q6PEY2 6/20 0.86
TUBA1A Q71U36 6/20 0.86
TUBA1C Q9BQE3 6/20 0.86
TUBB6 Q9BUF5 6/20 0.86
TUBB2B Q9BVA1 6/20 0.86
TUBB1 Q9H4B7 6/20 0.86
NR0B1 P51843 1/20 0.86
MKNK2 Q9HBH9 1/20 0.86
MAPT P10636 2/20 0.82
MEN1 O00255 1/20 0.82
POLB P06746 1/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Casticin SCHEMBL30442880 1.00 TUBB4A (0.86) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Casticin SCHEMBL382354 1.00 TUBB4A (0.86) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Chrysosplenol D SCHEMBL11133546 0.93 ALOX5 (0.83) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Centaureidin SCHEMBL9953 0.93 TUBB4A (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Chrysosplenol D SCHEMBL29359614 0.93 ALOX5 (0.83) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL10432667 0.93 MKNK2 (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Artemetin SCHEMBL2122576 0.91 TUBB4A (0.84) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Artemetin SCHEMBL29550082 0.91 TUBB4A (0.84) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL30082745 0.91 MEN1 (0.84) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Artemetin SCHEMBL29416756 0.91 TUBB4A (0.84) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115315195-B Hydroxy-and methoxy-substituted flavonoids and use thereof 弗门尼舍有限公司 2024-07-02 CN claimed
CN-115315195-A Hydroxy-and methoxy-substituted flavonoids and their use 弗门尼舍有限公司 2022-11-08 CN claimed
WO-2024189607-A1 METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR DISEASES TREATMENT DIDENKO KIRILL (MX) 2024-09-19 WO disclosed
CN-115315195-B Hydroxy-and methoxy-substituted flavonoids and use thereof 弗门尼舍有限公司 2024-07-02 CN disclosed
EP-4258900-A1 HYDROXY- AND METHOXY-SUBSTITUTED FLAVONOIDS AND THEIR USE Firmenich SA (CH) 2023-10-18 EP disclosed
CN-115315195-A Hydroxy-and methoxy-substituted flavonoids and their use 弗门尼舍有限公司 2022-11-08 CN disclosed
WO-2022189156-A1 HYDROXY- AND METHOXY-SUBSTITUTED FLAVONOIDS AND THEIR USE FIRMENICH SA (CH) 2022-09-15 WO disclosed