Chrysosplenol D

Chrysosplenol D

SCHEMBL29359614

COc1cc2oc(-c3ccc(O)c(O)c3)c(OC)c(=O)c2c(O)c1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 6/20 0.83
XDH P47989 1/20 0.82
ABCB1 P08183 1/20 0.78
ABCG2 Q9UNQ0 1/20 0.78
TUBB4A P04350 3/20 0.74
TUBB P07437 3/20 0.74
TUBA3C P0DPH7 3/20 0.74
TUBA1B P68363 3/20 0.74
TUBA4A P68366 3/20 0.74
TUBB4B P68371 3/20 0.74
TUBB3 Q13509 3/20 0.74
TUBB2A Q13885 3/20 0.74
TUBB8 Q3ZCM7 3/20 0.74
TUBA3E Q6PEY2 3/20 0.74
TUBA1A Q71U36 3/20 0.74
TUBA1C Q9BQE3 3/20 0.74
TUBB6 Q9BUF5 3/20 0.74
TUBB2B Q9BVA1 3/20 0.74
TUBB1 Q9H4B7 3/20 0.74
NR0B1 P51843 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chrysosplenol D SCHEMBL11133546 1.00 ALOX5 (0.83) ALOX5XDHABCB1ABCG2TUBB4A
Casticin SCHEMBL30442880 0.93 TUBB4A (0.86) ALOX5XDHABCB1ABCG2TUBB4A
Casticin SCHEMBL382354 0.93 TUBB4A (0.86) ALOX5XDHABCB1ABCG2TUBB4A
SCHEMBL31058466 0.93 MKNK2 (0.86) ALOX5XDHABCB1ABCG2MKNK2
Casticin SCHEMBL29926095 0.93 TUBB4A (0.86) ALOX5XDHABCB1ABCG2TUBB4A
SCHEMBL29143220 0.93 MKNK2 (0.86) ALOX5XDHABCB1ABCG2MKNK2
SCHEMBL2928366 0.93 XDH (0.78) ALOX5XDHABCB1ABCG2TUBB4A
Chrysosplenol B SCHEMBL29558792 0.93 ABCG2 (0.78) ALOX5XDHABCB1ABCG2TUBB4A
Chrysosplenol B SCHEMBL2369883 0.93 ABCG2 (0.78) ALOX5XDHABCB1ABCG2TUBB4A
SCHEMBL29024597 0.91 ALOX5 (0.76) ALOX5XDHABCB1ABCG2TUBB4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4650777-A1 NOVEL METHOD AND FLOW CYTOMETRY PANELS FOR IMMUNOPHENOTYPING Fundación para la Investigación Biomédica del Hospital Gregorio Marañón (FIBHGM) (ES) 2025-11-19 EP disclosed
US-12377079-B2 Antibacterial compounds and uses thereof THE CHILDREN'S MEDICAL CENTER CORPORATION 2025-08-05 US disclosed
CN-116473858-B Whitening application of opal D 上海家化联合股份有限公司 2025-05-06 CN disclosed
CN-116473858-A Whitening application of opal D 上海家化联合股份有限公司 2023-07-25 CN disclosed
CN-116350531-A Anti-glycation application of opal D 上海家化联合股份有限公司 2023-06-30 CN disclosed
CN-116327626-A Application of opal D in promotion of collagen and/or elastin production 上海家化联合股份有限公司 2023-06-27 CN disclosed
US-20220023270-A1 ANTIBACTERIAL COMPOUNDS AND USES THEREOF THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2022-01-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12377079-B2 Antibacterial compounds and uses thereof CLPP, SPOUT1, MRPL21 ALOX5 1206/4885XDH 272/4885ABCB1 347/4885
US-20220023270-A1 ANTIBACTERIAL COMPOUNDS AND USES THEREOF CLPP, SPOUT1, MRPL21 ALOX5 1206/4885XDH 272/4885ABCB1 347/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.