Casticin

Casticin

SCHEMBL382354

COc1ccc(-c2oc3cc(OC)c(OC)c(O)c3c(=O)c2OC)cc1O

nearest known ligand 0.86

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A P04350 6/20 0.86
TUBB P07437 6/20 0.86
TUBA3C P0DPH7 6/20 0.86
TUBA1B P68363 6/20 0.86
TUBA4A P68366 6/20 0.86
TUBB4B P68371 6/20 0.86
TUBB3 Q13509 6/20 0.86
TUBB2A Q13885 6/20 0.86
TUBB8 Q3ZCM7 6/20 0.86
TUBA3E Q6PEY2 6/20 0.86
TUBA1A Q71U36 6/20 0.86
TUBA1C Q9BQE3 6/20 0.86
TUBB6 Q9BUF5 6/20 0.86
TUBB2B Q9BVA1 6/20 0.86
TUBB1 Q9H4B7 6/20 0.86
NR0B1 P51843 1/20 0.86
MKNK2 Q9HBH9 1/20 0.86
MAPT P10636 2/20 0.82
MEN1 O00255 1/20 0.82
POLB P06746 1/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Casticin SCHEMBL30442880 1.00 TUBB4A (0.86) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Casticin SCHEMBL29926095 1.00 TUBB4A (0.86) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Chrysosplenol D SCHEMBL11133546 0.93 ALOX5 (0.83) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Centaureidin SCHEMBL9953 0.93 TUBB4A (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Chrysosplenol D SCHEMBL29359614 0.93 ALOX5 (0.83) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL10432667 0.93 MKNK2 (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Artemetin SCHEMBL2122576 0.91 TUBB4A (0.84) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Artemetin SCHEMBL29550082 0.91 TUBB4A (0.84) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL30082745 0.91 MEN1 (0.84) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Artemetin SCHEMBL29416756 0.91 TUBB4A (0.84) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 424 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 EP claimed
WO-2024258363-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES SAHIN FIKRET (TR) 2024-12-19 WO claimed
CN-118006548-B Biological agent for treating knee arthritis 超越再生医学(杭州)有限公司 2024-08-30 CN claimed
CN-118006548-A Biological agent for treating knee arthritis 超越健康科技(浙江)有限公司 2024-05-10 CN claimed
US-20240099344-A1 HYDROXY- AND METHOXY-SUBSTITUTED FLAVONOIDS AND THEIR USE FIRMENICH SA (CH) 2024-03-28 US claimed
US-20240026314-A1 POLYPEPTIDES FOR USE IN THE SYNTHESIS OF BIOACTIVE PHENOLIC COMPOUNDS ROTHSTEIN STEVEN (CA) 2024-01-25 US claimed
CN-116999477-A Preparation and application of herba Artemisiae Annuae sesquiterpene extract external preparation for treating inflammatory dermatoses 首都医科大学 2023-11-07 CN claimed
EP-4258900-A1 HYDROXY- AND METHOXY-SUBSTITUTED FLAVONOIDS AND THEIR USE Firmenich SA (CH) 2023-10-18 EP claimed
EP-4251758-A1 POLYPEPTIDES FOR USE IN THE SYNTHESIS OF BIOACTIVE PHENOLIC COMPOUNDS Rothstein, Steven (CA) 2023-10-04 EP claimed
CN-116712493-A Application of tendril Jing Zishui extract in preparation of migraine treatment medicine 天津中医药大学 2023-09-08 CN claimed
CN-100560084-C Method and preparation having antiallergic effect DENOVASTELLA AB (SE) 2009-11-18 CN claimed
WO-2009118338-A2 USE OF A POLYPHENOLIC TYPE COMPOUND FOR PREVENTING OR TREATING A POLYGLUTAMINE EXPANSION NEURODEGENERATIVE DISEASE INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2009-10-01 WO claimed
US-20080249164-A1 Antimicrobial and Antinflammatory Composition DENOVASTELLA AB (SE) 2008-10-09 US claimed
US-20080160083-A1 Delivering effective amounts of Chasteberry Extract, Pyridoxine, and Magnesium in a single dosage unit and a method of treating PMS and related disorders; oral dosage NORTHERN HOLDINGS INC. 2008-07-03 US claimed
EP-1898893-A1 ANTIMICROBIAL AND ANTIINFLAMMATORY COMPOSITION Denovastella AB (SE) 2008-03-19 EP claimed
CN-101028261-A Use of casticin in preparation of medicine against premenstrual syndrome NO 2 MILITARY MEDICAL UNIV OF (CN) 2007-09-05 CN claimed
EP-1776071-A2 COATED VAGINAL DEVICES FOR VAGINAL DELIVERY OF THERAPEUTICALLY EFFECTIVE AND/ OR HEALTH-PROMOTING AGENTS UMD, Inc. (US) 2007-04-25 EP claimed
WO-2007004952-A1 ANTIMICROBIAL AND ANTIINFLAMMATORY COMPOSITION DENOVASTELLA AB (SE) 2007-01-11 WO claimed
WO-2006017341-A2 COATED VAGINAL DEVICES FOR VAGINAL DELIVERY OF THERAPEUTICALLY EFFECTIVE AND/ OR HEALTH-PROMOTING AGENTS UMD, INC. (US) 2006-02-16 WO claimed
US-20050276836-A1 Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents UMD, INC. 2005-12-15 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080160083-A1 Delivering effective amounts of Chasteberry Extract, Pyridoxine, and Magnesium in a single dosage unit and a method of treating PMS and related disorders; oral dosage PNPO, PRDX5, PGR TUBB4A 3561/4885TUBB 2629/4885TUBA3C 3464/4885
US-20240026314-A1 POLYPEPTIDES FOR USE IN THE SYNTHESIS OF BIOACTIVE PHENOLIC COMPOUNDS COMT, PNMT, GNMT TUBB4A 3257/4885TUBB 3882/4885TUBA3C 4487/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.