Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.51 |
| ▸ | PLAU | P00749 | 2/20 | 0.49 |
| ▸ | F12 | P00748 | 2/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | NOS3 | P29474 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
| ▸ | NOS2 | P35228 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | SORD | Q00796 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12779077 | 0.79 | AXL (0.71) | AXLPLAUF12NCF1NOS3 | |
| SCHEMBL29928526 | 0.75 | HTR2C (0.46) | AXLHTR2CALDH1A1 | |
| SCHEMBL29928245 | 0.74 | ATM (0.49) | ALDH1A1MAPTRAB9ASMN1; SMN2ATM | |
| SCHEMBL6086513 | 0.73 | PLAU (0.47) | AXLPLAUF12NCF1NOS3 | |
| SCHEMBL29929480 | 0.69 | FLT3 (0.55) | AXLNPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL15824969 | 0.69 | HRH4 (0.46) | PLAUF12NCF1NOS3NOS1 | |
| SCHEMBL29928610 | 0.69 | MEN1 (0.49) | AXLNCF1BACE1HRH4ALDH1A1 | |
| SCHEMBL5202901 | 0.68 | COMT (0.58) | PLAUF12NCF1NOS3NOS1 | |
| SCHEMBL8942018 | 0.67 | TSHR (0.58) | NPC1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4635351 | 0.67 | HRH4 (0.55) | AXLPLAUF12NCF1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110551105-B | Substituted triazoles useful as AXL inhibitors | 里格尔制药公司 | 2022-10-18 | — | — | CN | claimed |
| CN-110551105-B | Substituted triazoles useful as AXL inhibitors | 里格尔制药公司 | 2022-10-18 | — | — | CN | disclosed |