Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 9/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29927676 | 0.78 | ATM (0.69) | ATMPIK3CAPIK3CBMTORPRKDC | |
| SCHEMBL29927588 | 0.74 | AXL (0.51) | ATMPIK3CAPIK3CBMTORPRKDC | |
| SCHEMBL15595899 | 0.73 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTGAATDP1L3MBTL1 | |
| SCHEMBL29929117 | 0.72 | SMN1; SMN2 (0.55) | ATMPIK3CAPIK3CBMTORPRKDC | |
| SCHEMBL4236664 | 0.72 | AXL (0.77) | — | |
| SCHEMBL4774035 | 0.69 | ACHE (0.60) | SMN1; SMN2CYP3A4USP2ALDH1A1LMNA | |
| SCHEMBL29928526 | 0.69 | HTR2C (0.46) | ALDH1A1KDM4E | |
| SCHEMBL2919337 | 0.69 | NCF1 (0.60) | MAPTCYP3A4USP2ALDH1A1CYP1A2 | |
| SCHEMBL3974591 | 0.68 | CYP3A4 (0.54) | SMN1; SMN2MAPTGAATDP1L3MBTL1 | |
| SCHEMBL30458203 | 0.68 | CYP3A4 (0.54) | SMN1; SMN2MAPTGAATDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110551105-B | Substituted triazoles useful as AXL inhibitors | 里格尔制药公司 | 2022-10-18 | — | — | CN | claimed |
| CN-110551105-B | Substituted triazoles useful as AXL inhibitors | 里格尔制药公司 | 2022-10-18 | — | — | CN | disclosed |