Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.47 |
| ▸ | NCF1 | P14598 | 2/20 | 0.47 |
| ▸ | F12 | P00748 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | SORD | Q00796 | 2/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15824969 | 0.78 | HRH4 (0.46) | PLAUNCF1F12NOS3NOS1 | |
| SCHEMBL6086442 | 0.75 | KDM4E (0.45) | NOS3NOS1NOS2MALT1ALDH1A1 | |
| SCHEMBL10545578 | 0.74 | NPC1 (0.64) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL29927588 | 0.73 | AXL (0.51) | PLAUNCF1F12NOS3NOS1 | |
| SCHEMBL6087233 | 0.72 | NCF1 (0.51) | NCF1MALT1MAPTHTT | |
| SCHEMBL16566305 | 0.72 | PLAU (0.47) | PLAUNCF1F12NOS3NOS1 | |
| SCHEMBL6088573 | 0.69 | ALDH1A1 (0.47) | NCF1ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL3252316 | 0.68 | RAB9A (0.52) | NOS3NOS1NOS2ALDH1A1NPC1 | |
| SCHEMBL6087436 | 0.68 | CYP17A1 (0.51) | BACE1AXLNPC1MAPTRAB9A | |
| SCHEMBL5202901 | 0.67 | COMT (0.58) | PLAUNCF1F12NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7056354-B2 | Compounds derived from diaminopyrazole substituted by a heteroaromatic radical and their use in oxidation dyeing of keratinous fibers | L'OREAL (FR) | 2006-06-06 | — | — | US | claimed |
| US-20040255397-A1 | Compounds derived from diaminopyrazole substituted by a heteroaromatic radical and their use in oxidation dyeing of keratimous fibers | L'OREAL (FR) | 2004-12-23 | — | — | US | claimed |
| EP-1412348-A1 | COMPOUNDS DERIVED FROM DIAMINOPYRAZOLE SUBSTITUTED BY A HETEROAROMATIC RADICAL AND THEIR USE IN OXIDATION DYEING OF KERATINOUS FIBRES | L'OREAL (FR) | 2004-04-28 | — | — | EP | claimed |
| WO-2003008405-A1 | COMPOUNDS DERIVED FROM DIAMINOPYRAZOLE SUBSTITUTED BY A HETEROAROMATIC RADICAL AND THEIR USE IN OXIDATION DYEING OF KERATINOUS FIBRES | L'OREAL (FR) | 2003-01-30 | — | — | WO | claimed |
| US-7056354-B2 | Compounds derived from diaminopyrazole substituted by a heteroaromatic radical and their use in oxidation dyeing of keratinous fibers | L'OREAL (FR) | 2006-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040255397-A1 | Compounds derived from diaminopyrazole substituted by a heteroaromatic radical and their use in oxidation dyeing of keratimous fibers | KRT18, AOC1, XRCC5 | PLAU 4213/4885NCF1 2196/4885F12 241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.