Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CCNH | P51946 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 10/20 | 0.40 |
| ▸ | JAK2 | O60674 | 9/20 | 0.40 |
| ▸ | TYK2 | P29597 | 6/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.39 |
| ▸ | STAT3 | P40763 | 4/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27241032 | 1.00 | CCNT1 (0.42) | CCNT1CDK2CDK9CCNE2CCNE1 | |
| SCHEMBL27240942 | 0.89 | JAK2 (0.48) | CCNT1CDK2CDK9CCNE2CCNE1 | |
| SCHEMBL27240978 | 0.85 | TBK1 (0.42) | JAK1JAK2TYK2TBK1STAT3 | |
| SCHEMBL29929573 | 0.85 | TBK1 (0.42) | JAK1JAK2TYK2TBK1STAT3 | |
| SCHEMBL26977284 | 0.82 | CDK2 (0.38) | CCNT1CDK2CDK9CDK1CCNB1 | |
| SCHEMBL30671845 | 0.80 | TBK1 (0.42) | CDK2CDK9CDK7JAK1JAK2 | |
| SCHEMBL26979795 | 0.80 | JAK3 (0.49) | JAK1JAK2JAK3 | |
| SCHEMBL29929049 | 0.80 | VCAM1 (0.41) | PIK3CD | |
| SCHEMBL26977398 | 0.80 | VCAM1 (0.41) | PIK3CD | |
| SCHEMBL23611947 | 0.80 | CDK2 (0.38) | CCNT1CDK2CDK9CCNE2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4297873-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | Tyra Biosciences, Inc. (US) | 2024-01-03 | — | — | EP | disclosed |
| CN-117136184-A | Aminopyrimidine compounds and methods of use thereof | 泰拉生物科学公司 | 2023-11-28 | — | — | CN | disclosed |
| WO-2022182972-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | TYRA BIOSCIENCES, INC. (US) | 2022-09-01 | — | — | WO | disclosed |