Amentoflavone

Amentoflavone

SCHEMBL29929632

O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12

nearest known ligand 0.80

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.80
THRB P10828 3/20 0.80
KMT2A Q03164 3/20 0.80
TDP1 Q9NUW8 3/20 0.80
PARP1 P09874 11/20 0.77
PARP2 Q9UGN5 7/20 0.77
PTPN1 P18031 3/20 0.70
APP P05067 4/20 0.69
CDK5 Q00535 3/20 0.69
CDK5R1 Q15078 3/20 0.69
KDM4E B2RXH2 3/20 0.69
CYP3A4 P08684 3/20 0.69
MAPT P10636 3/20 0.69
BACE1 P56817 3/20 0.69
PKM P14618 2/20 0.69
APEX1 P27695 2/20 0.69
SLC22A2 O15244 2/20 0.69
SLC22A1 O15245 2/20 0.69
AKR1B10 O60218 2/20 0.69
SLCO2B1 O94956 2/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Amentoflavone SCHEMBL29497539 1.00 MEN1 (0.80) MEN1THRBKMT2ATDP1PARP1
Amentoflavone SCHEMBL312563 1.00 MEN1 (0.80) MEN1THRBKMT2ATDP1PARP1
Amentoflavone SCHEMBL4649212 0.99 MEN1 (0.79) MEN1THRBKMT2ATDP1PARP1
Podocarpusflavone A SCHEMBL29496316 0.90 MEN1 (0.72) MEN1THRBKMT2ATDP1PARP1
Podocarpusflavone A SCHEMBL25937932 0.90 MEN1 (0.72) MEN1THRBKMT2ATDP1PARP1
Amentoflavone SCHEMBL7642601 0.90 MEN1 (0.66) MEN1THRBKMT2ATDP1PARP1
Sequoiaflavone SCHEMBL1158361 0.89 MEN1 (0.73) MEN1THRBKMT2ATDP1PARP1
Sequoiaflavone SCHEMBL30646160 0.89 MEN1 (0.73) MEN1THRBKMT2ATDP1PARP1
Sumaflavone SCHEMBL13980979 0.89 KMT2A (0.74) MEN1THRBKMT2ATDP1PARP1
Sumaflavone SCHEMBL30152146 0.89 KMT2A (0.74) MEN1THRBKMT2ATDP1PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023064318-A1 BIPHASIC COMPOSITIONS COMPRISING ONE OR BOTH OF CARBONATE AND PHOSPHATE Natural Extraction Systems, LLC (US) 2023-04-20 WO claimed
WO-2022182527-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2022-09-01 WO claimed
WO-2023064318-A1 BIPHASIC COMPOSITIONS COMPRISING ONE OR BOTH OF CARBONATE AND PHOSPHATE Natural Extraction Systems, LLC (US) 2023-04-20 WO disclosed