Amentoflavone

Amentoflavone

SCHEMBL312563

O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12

nearest known ligand 0.80

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.80
THRB P10828 3/20 0.80
KMT2A Q03164 3/20 0.80
TDP1 Q9NUW8 3/20 0.80
PARP1 P09874 11/20 0.77
PARP2 Q9UGN5 7/20 0.77
PTPN1 P18031 3/20 0.70
APP P05067 4/20 0.69
CDK5 Q00535 3/20 0.69
CDK5R1 Q15078 3/20 0.69
KDM4E B2RXH2 3/20 0.69
CYP3A4 P08684 3/20 0.69
MAPT P10636 3/20 0.69
BACE1 P56817 3/20 0.69
PKM P14618 2/20 0.69
APEX1 P27695 2/20 0.69
SLC22A2 O15244 2/20 0.69
SLC22A1 O15245 2/20 0.69
AKR1B10 O60218 2/20 0.69
SLCO2B1 O94956 2/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Amentoflavone SCHEMBL29929632 1.00 MEN1 (0.80) MEN1THRBKMT2ATDP1PARP1
Amentoflavone SCHEMBL29497539 1.00 MEN1 (0.80) MEN1THRBKMT2ATDP1PARP1
Amentoflavone SCHEMBL4649212 0.99 MEN1 (0.79) MEN1THRBKMT2ATDP1PARP1
Podocarpusflavone A SCHEMBL29496316 0.90 MEN1 (0.72) MEN1THRBKMT2ATDP1PARP1
Podocarpusflavone A SCHEMBL25937932 0.90 MEN1 (0.72) MEN1THRBKMT2ATDP1PARP1
Amentoflavone SCHEMBL7642601 0.90 MEN1 (0.66) MEN1THRBKMT2ATDP1PARP1
Sequoiaflavone SCHEMBL1158361 0.89 MEN1 (0.73) MEN1THRBKMT2ATDP1PARP1
Sequoiaflavone SCHEMBL30646160 0.89 MEN1 (0.73) MEN1THRBKMT2ATDP1PARP1
Sumaflavone SCHEMBL13980979 0.89 KMT2A (0.74) MEN1THRBKMT2ATDP1PARP1
Sumaflavone SCHEMBL30152146 0.89 KMT2A (0.74) MEN1THRBKMT2ATDP1PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2241 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122024846-A Screening method of natural compound for resisting macrobrachium rosenbergii iridovirus based on MCP protein target spot 中国水产科学研究院淡水渔业研究中心 2026-05-12 CN claimed
CN-117462576-B Active component in herba Selaginellae and application thereof in inhibiting alpha-glucosidase 湖南科技学院 2026-02-27 CN claimed
EP-4691473-A1 PLATYCLADUS ORIENTALIS EXTRACT, PREPARATION METHOD THEREFOR AND USE THEREOF Beijing Academy of TCM Beauty Supplements Co., Ltd. (CN) 2026-02-11 EP claimed
US-20250339399-A1 SUPRAMOLECULAR SELF-ASSEMBLY SYSTEM BEIJING CREATRON INSTITUTE OF PHARMACEUTICAL RES CO LTD (CN) 2025-11-06 US claimed
US-12390503-B2 Ginkgo biloba leave extract capsule and preparation method therefor SPH XING LING SCI. & TECH. PHARMACEUTICAL CO., LTD. (CN) 2025-08-19 US claimed
CN-120053331-A Skin care composition with anti-aging effect, preparation method and application thereof 广州荃智美肤生物科技研究院有限公司 2025-05-30 CN claimed
US-12311002-B2 Extract of Ginkgo biloba leaves and preparation method therefor SPH XING LING SCI. & TECH. PHARMACEUTICAL CO., LTD. (CN) 2025-05-27 US claimed
CN-119977932-A Preparation method of amentoflavone from Selaginella medicinal material 中国药科大学 2025-05-13 CN claimed
CN-119736251-A Recombinant cell CHO@hTYR, novel tyrosinase inhibitor extraction method and novel tyrosinase inhibitor 深圳市护家科技有限公司 2025-04-01 CN claimed
CN-119661489-A Method for extracting amentoflavone and apigenin from herba Selaginellae 江西康隆莱健生物科技有限公司 2025-03-21 CN claimed
US-5679358-A TOPICAL APPLICATION; INCLUDES AN ADENYLATE CYCLASE STIMULATOR, A PHOSPHODIESTERASE INHIBITOR AND/OR A LIPOLYTIC AGENT INDENA S.A. (IT) 1997-10-21 US claimed
WO-1997017056-A1 COSMETIC COMPOSITION CONTAINING A VIBURNUM EXTRACT PIERRE FABRE DERMO-COSMETIQUE (FR) 1997-05-15 WO claimed
WO-1997000679-A1 BIFLAVANOIDS AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS MEDICHEM RESEARCH, INC. (US) 1997-01-09 WO claimed
WO-1996027384-A2 COMPOSITION FOR TREATING SKIN CONDITIONS COMPRISING AN INHIBITOR OF SKIN ISO-PHOSPHODIESTERASE PARFUMS CHRISTIAN DIOR (FR) 1996-09-12 WO claimed
EP-0714296-A1 FLAVONOID AND BIFLAVONOID DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS, THEIR ANXIOLYTIC ACTIVITY UNIVERSITY OF STRATHCLYDE (GB) 1996-06-05 EP claimed
EP-0692250-A2 Formulations containing esculoside and the use thereof in the pharmaceutical and cosmetic fields INDENA S.p.A. (IT) 1996-01-17 EP claimed
EP-0427026-B1 Compositions for treating fat deposits in humans INDENA SPA (IT) 1995-10-11 EP claimed
WO-1995005169-A1 FLAVONOID AND BIFLAVONOID DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS, THEIR ANXIOLYTIC ACTIVITY THE UNIVERSITY OF STRATHCLYDE (GB) 1995-02-23 WO claimed
US-5376371-A Topical; extracts from Salvia and Ginkgo leaves with excipient ; adenylate cyclase agonist and phosphodiesterase inhibitor INDENA S.P.A. (IT) 1994-12-27 US claimed
EP-0427026-A2 Compositions for treating fat deposits in humans INDENA S.p.A. (IT) 1991-05-15 EP claimed