Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 3/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 8/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930600 | 0.87 | HDAC8 (0.36) | DGAT1MAPTBRD4CREBBPALOX5AP | |
| SCHEMBL29930814 | 0.81 | PDGFRB (0.41) | DGAT1 | |
| SCHEMBL29930433 | 0.80 | DGAT1 (0.41) | DGAT1PIK3CAMAPTALDH1A1HSD17B10 | |
| SCHEMBL29930423 | 0.80 | MAP4K4 (0.40) | DGAT1BRD4CREBBPALOX5APFEN1 | |
| SCHEMBL29705469 | 0.79 | DGAT1 (0.33) | DGAT1MAPT | |
| SCHEMBL19023260 | 0.79 | DGAT1 (0.33) | DGAT1MAPT | |
| SCHEMBL1565921 | 0.79 | DGAT1 (0.40) | DGAT1HSD17B10 | |
| SCHEMBL18188139 | 0.79 | DGAT1 (0.33) | DGAT1ALOX5APFEN1 | |
| SCHEMBL31469272 | 0.78 | DGAT1 (0.35) | DGAT1MAPTBRD4CREBBPALOX5AP | |
| SCHEMBL29930774 | 0.78 | DGAT1 (0.41) | DGAT1GRIN1GRIN2BBRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |