Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 10/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 10/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | FLT4 | P35916 | 2/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930600 | 0.81 | HDAC8 (0.36) | DGAT1 | |
| SCHEMBL29930403 | 0.81 | FTO (0.39) | DGAT1 | |
| SCHEMBL29930423 | 0.79 | MAP4K4 (0.40) | DGAT1 | |
| SCHEMBL31469272 | 0.78 | DGAT1 (0.35) | DGAT1 | |
| SCHEMBL29930774 | 0.78 | DGAT1 (0.41) | GAKDGAT1 | |
| SCHEMBL29930433 | 0.78 | DGAT1 (0.41) | PDGFRBPDGFRADGAT1 | |
| SCHEMBL1565921 | 0.76 | DGAT1 (0.40) | DGAT1 | |
| SCHEMBL29705469 | 0.76 | DGAT1 (0.33) | DGAT1 | |
| SCHEMBL18188139 | 0.76 | DGAT1 (0.33) | DGAT1 | |
| SCHEMBL19023260 | 0.76 | DGAT1 (0.33) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |