Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.38 |
| ▸ | FEN1 | P39748 | 4/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.36 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.34 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.34 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | EPHB1 | P54762 | 1/20 | 0.34 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.34 |
| ▸ | SIK1 | P57059 | 1/20 | 0.34 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930600 | 0.79 | HDAC8 (0.36) | DGAT1ALOX5APFEN1F2RL1BRD4 | |
| SCHEMBL29930403 | 0.78 | FTO (0.39) | DGAT1ALOX5APFEN1GRIN2BGRIN1 | |
| SCHEMBL16536822 | 0.78 | F2RL1 (0.35) | DGAT1ALOX5APFEN1GRIN2BF2RL1 | |
| SCHEMBL29930814 | 0.78 | PDGFRB (0.41) | DGAT1GAK | |
| SCHEMBL31469272 | 0.78 | DGAT1 (0.35) | DGAT1ALOX5APFEN1BRD4CREBBP | |
| SCHEMBL29930423 | 0.77 | MAP4K4 (0.40) | DGAT1ALOX5APFEN1BRD4CREBBP | |
| SCHEMBL1565921 | 0.76 | DGAT1 (0.40) | DGAT1F2RL1 | |
| SCHEMBL29705469 | 0.76 | DGAT1 (0.33) | DGAT1F2RL1 | |
| SCHEMBL18188139 | 0.76 | DGAT1 (0.33) | DGAT1ALOX5APFEN1F2RL1 | |
| SCHEMBL19023260 | 0.76 | DGAT1 (0.33) | DGAT1F2RL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |