Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930403 | 0.87 | FTO (0.39) | DGAT1MAPTALOX5APFEN1BRD4 | |
| SCHEMBL29930814 | 0.81 | PDGFRB (0.41) | DGAT1 | |
| SCHEMBL29930423 | 0.81 | MAP4K4 (0.40) | DGAT1CHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL18188139 | 0.80 | DGAT1 (0.33) | DGAT1ALOX5APFEN1F2RL1 | |
| SCHEMBL19023260 | 0.80 | DGAT1 (0.33) | DGAT1MAPTF2RL1 | |
| SCHEMBL29705469 | 0.80 | DGAT1 (0.33) | DGAT1MAPTF2RL1 | |
| SCHEMBL1565921 | 0.80 | DGAT1 (0.40) | HDAC8DGAT1F2RL1 | |
| SCHEMBL31469272 | 0.79 | DGAT1 (0.35) | DGAT1MAPTALOX5APFEN1BRD4 | |
| SCHEMBL29930774 | 0.79 | DGAT1 (0.41) | DGAT1ALOX5APFEN1BRD4CREBBP | |
| SCHEMBL29705384 | 0.79 | HPGDS (0.36) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |