Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 4/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.33 |
| ▸ | FEN1 | P39748 | 4/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
| ▸ | PDE1A | P54750 | 1/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1592834 | 0.89 | MERTK (0.39) | DYRK1BMERTKDGAT1ALOX5APFEN1 | |
| SCHEMBL29930815 | 0.87 | AXL (0.41) | DYRK1BMERTKDGAT1NPC1AXL | |
| SCHEMBL30645456 | 0.85 | DGAT1 (0.36) | DGAT1ALOX5APFEN1 | |
| SCHEMBL29113927 | 0.85 | DGAT1 (0.36) | DGAT1ALOX5APFEN1 | |
| SCHEMBL29930812 | 0.84 | PDE4A (0.39) | — | |
| SCHEMBL29930809 | 0.83 | DGAT1 (0.37) | DYRK1BMERTKDGAT1NPC1AXL | |
| SCHEMBL29930508 | 0.83 | DGAT1 (0.36) | DYRK1BMERTKDGAT1PDE1B | |
| SCHEMBL29930779 | 0.82 | AXL (0.41) | DYRK1BMERTKDGAT1MAP4K4AXL | |
| SCHEMBL29930954 | 0.82 | DYRK1A (0.46) | DYRK1BPDE5APDE1APDE1BPDE3B | |
| SCHEMBL29930401 | 0.81 | DYRK1B (0.40) | DYRK1BMERTKDGAT1AXLPDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |