Sugi Predict

Sugi Predict / Compounds / SCHEMBL1592834

SCHEMBL1592834

SCHEMBL1592834

C[Si](C)(C)CCOCn1nc(-c2ccccc2)c2cc(Br)cnc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MERTK Q12866 12/20 0.39
▸ DGAT1 O75907 3/20 0.37
▸ ALDH1A1 P00352 1/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ CYP3A4 P08684 1/20 0.35
▸ CYP2C9 P11712 1/20 0.35
▸ CYP2C19 P33261 1/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ AXL P30530 4/20 0.34
▸ TYRO3 Q06418 4/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ DYRK1B Q9Y463 1/20 0.33
▸ PLK4 O00444 1/20 0.33
▸ AURKA O14965 1/20 0.33
▸ JAK2 O60674 1/20 0.33
▸ ROCK2 O75116 1/20 0.33
▸ PRKD3 O94806 1/20 0.33
▸ MAP4K4 O95819 1/20 0.33
▸ PRKCG P05129 1/20 0.33
▸ INSR P06213 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29930809 0.90 DGAT1 (0.37) MERTKDGAT1ALDH1A1NPSR1AXL
SCHEMBL29930779 0.89 AXL (0.41) MERTKDGAT1ALDH1A1CYP1A2CYP3A4
SCHEMBL29930820 0.89 GSK3B (0.41) MERTKDGAT1ALDH1A1AXLTYRO3
SCHEMBL29930407 0.89 DYRK1B (0.39) MERTKDGAT1AXLTYRO3NPC1
SCHEMBL29930815 0.88 AXL (0.41) MERTKDGAT1ALDH1A1NPSR1AXL
SCHEMBL29930508 0.88 DGAT1 (0.36) MERTKDGAT1DYRK1BDYRK1A
SCHEMBL27215091 0.87 MERTK (0.39) MERTKALDH1A1AXLTYRO3NPC1
SCHEMBL29930401 0.86 DYRK1B (0.40) MERTKDGAT1AXLDYRK1BAURKA
SCHEMBL29930558 0.86 DYRK1B (0.48) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL29930775 0.86 MAPT (0.35) DGAT1ALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240150345-A1 GCN2 MODULATING COMPOUNDS AND USES THEREOF PHARMARON UK LTD. (GB) 2024-05-09 — — US disclosed
WO-2022235097-A1 PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS 한국화학연구원 2022-11-10 — — WO disclosed
WO-2022159745-A1 GCN2 MODULATING COMPOUNDS AND USES THEREOF HIBERCELL, INC. (US) 2022-07-28 — — WO disclosed
US-8394795-B2 Pyrazole [3, 4-B] pyridine Raf inhibitors ARRAY BIOPHARMA INC. (US) 2013-03-12 — — US disclosed
EP-2265610-B1 PYRAZOLE [3, 4-B]PYRIDINE RAF INHIBITORS ARRAY BIOPHARMA INC (US) 2012-12-12 — — EP disclosed
US-20110092479-A1 PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS ARRAY BIOPHARMA INC. (US) 2011-04-21 — — US disclosed
EP-2265610-A1 PYRAZOLE [3, 4-B]PYRIDINE RAF INHIBITORS Array Biopharma, Inc. (US) 2010-12-29 — — EP disclosed
WO-2009111279-A1 PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS ARRAY BIOPHARMA INC. (US) 2009-09-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240150345-A1 GCN2 MODULATING COMPOUNDS AND USES THEREOF EIF2AK4, GCN1, CLN6 MERTK 4703/4885DGAT1 565/4885ALDH1A1 4164/4885
US-20110092479-A1 PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS BRAF, RAF1, ARAF MERTK 1016/4885DGAT1 4252/4885ALDH1A1 1210/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.