Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.73 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.65 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.45 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.45 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | GRK2 | P25098 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | CTSV | O60911 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930851 | 0.92 | DYRK1B (0.73) | DYRK1BDYRK1AMAOBSTK10SLK | |
| SCHEMBL29930889 | 0.90 | DYRK1B (0.69) | DYRK1BDYRK1ATP53MAPTABCB1 | |
| SCHEMBL29930763 | 0.85 | DYRK1B (0.71) | DYRK1BDYRK1ASTK10SLKTP53 | |
| SCHEMBL29930701 | 0.78 | DYRK1B (0.67) | DYRK1BDYRK1AMAPT | |
| SCHEMBL29930670 | 0.76 | DYRK1B (0.70) | DYRK1BDYRK1ASTK10SLKABCG2 | |
| SCHEMBL5533779 | 0.73 | DYRK1B (0.43) | DYRK1BDYRK1AMAPTTTKBCHE | |
| SCHEMBL29930535 | 0.73 | GAA (0.49) | DYRK1BDYRK1AMAPT | |
| SCHEMBL29930966 | 0.73 | KIT (0.50) | DYRK1BDYRK1ATTKBTK | |
| SCHEMBL28675336 | 0.72 | MAP4K1 (0.65) | MAPT | |
| SCHEMBL6098127 | 0.72 | CTSV (0.65) | MAOBSTK10SLKPTK6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | claimed |
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |