Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 6/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932118 | 0.87 | GAA (0.38) | GAAHTTLMNATP53SMN1; SMN2 | |
| SCHEMBL29931920 | 0.86 | GAA (0.37) | GAAHTTLMNATP53SMN1; SMN2 | |
| SCHEMBL29931995 | 0.84 | LMNA (0.38) | GAAHTTLMNATP53SMN1; SMN2 | |
| SCHEMBL29932225 | 0.82 | GAA (0.40) | GAAHTTLMNATP53SMN1; SMN2 | |
| SCHEMBL30232726 | 0.81 | LMNA (0.41) | GAAHTTLMNATP53SMN1; SMN2 | |
| SCHEMBL29932150 | 0.81 | LMNA (0.38) | GAAHTTLMNATP53SMN1; SMN2 | |
| SCHEMBL29932027 | 0.79 | ALDH1A1 (0.41) | GAAHTTLMNATP53SMN1; SMN2 | |
| SCHEMBL23536504 | 0.74 | DRD4 (0.42) | HTTLMNAALDH1A1POLBADORA2B | |
| SCHEMBL29931890 | 0.74 | DRD4 (0.42) | HTTLMNAALDH1A1POLBADORA2B | |
| SCHEMBL29931746 | 0.73 | ALDH1A1 (0.40) | GAAHTTLMNATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |