Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 5/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536478 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAGAAHTTTP53 | |
| SCHEMBL29932015 | 0.87 | SMN1; SMN2 (0.36) | SMN1; SMN2LMNAGAAHTTTP53 | |
| SCHEMBL23536460 | 0.81 | GAA (0.46) | SMN1; SMN2LMNAGAAHTTTP53 | |
| SCHEMBL29931785 | 0.77 | LMNA (0.44) | SMN1; SMN2LMNAGAAHTTTP53 | |
| SCHEMBL23536592 | 0.77 | LMNA (0.44) | SMN1; SMN2LMNAGAAHTTTP53 | |
| SCHEMBL23536538 | 0.75 | HTR6 (0.56) | SMN1; SMN2LMNAGAAHTTTP53 | |
| SCHEMBL23536583 | 0.71 | HTT (0.41) | SMN1; SMN2LMNAGAAHTTTP53 | |
| SCHEMBL29932117 | 0.70 | SMN1; SMN2 (0.37) | SMN1; SMN2LMNAGAAHTTTP53 | |
| SCHEMBL23536498 | 0.70 | LMNA (0.43) | SMN1; SMN2LMNAGAAHTTTP53 | |
| SCHEMBL29931923 | 0.70 | LMNA (0.43) | SMN1; SMN2LMNAGAAHTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |