Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931785 | 1.00 | LMNA (0.44) | LMNASMN1; SMN2GAAHTTTP53 | |
| SCHEMBL23536498 | 0.80 | LMNA (0.43) | LMNASMN1; SMN2GAAHTTTP53 | |
| SCHEMBL29931923 | 0.80 | LMNA (0.43) | LMNASMN1; SMN2GAAHTTTP53 | |
| SCHEMBL29931905 | 0.80 | LMNA (0.40) | LMNASMN1; SMN2GAAHTTTP53 | |
| SCHEMBL23536538 | 0.80 | HTR6 (0.56) | LMNASMN1; SMN2GAAHTTTP53 | |
| SCHEMBL23536297 | 0.80 | LMNA (0.40) | LMNASMN1; SMN2GAAHTTTP53 | |
| SCHEMBL29932129 | 0.77 | SMN1; SMN2 (0.45) | LMNASMN1; SMN2GAAHTTTP53 | |
| SCHEMBL23536478 | 0.77 | SMN1; SMN2 (0.45) | LMNASMN1; SMN2GAAHTTTP53 | |
| SCHEMBL29931746 | 0.76 | ALDH1A1 (0.40) | LMNASMN1; SMN2GAAHTTTP53 | |
| SCHEMBL29932004 | 0.76 | ALDH1A1 (0.40) | LMNASMN1; SMN2GAAHTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |