Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 11/20 | 0.60 |
| ▸ | FEN1 | P39748 | 3/20 | 0.52 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.52 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | PRKACG | P22612 | 1/20 | 0.44 |
| ▸ | PRKACB | P22694 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4558163 | 1.00 | DAO (0.60) | DAOFEN1ERCC5CA12RNASEH1 | |
| SCHEMBL9280731 | 0.81 | KDM4E (0.45) | DAOFEN1ERCC5CA12RNASEH1 | |
| SCHEMBL1382913 | 0.76 | PARP1 (0.42) | DAOCA12CA9LCKPRKACA | |
| SCHEMBL19673966 | 0.76 | ALDH1A1 (0.52) | DAOCA12CA9LCKPRKACA | |
| SCHEMBL5033267 | 0.76 | GPR3 (0.52) | DAOFEN1CA12ERCC1CA9 | |
| SCHEMBL27888984 | 0.76 | LCK (0.48) | DAOLCKPRKACACSNK2A2PRKACG | |
| SCHEMBL31741258 | 0.75 | DAO (1.00) | DAOFEN1ERCC5CA12RNASEH1 | |
| SCHEMBL7735923 | 0.75 | DAO (1.00) | DAOFEN1ERCC5CA12RNASEH1 | |
| SCHEMBL17501689 | 0.74 | PKM (0.42) | DAOCA12CA9LCKPRKACA | |
| Benzene SCHEMBL28335868 | 0.74 | ADORA3 (0.50) | DAOFEN1ERCC1ERCC4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353154-B3 | 3-HYDROXY-7-(SULFONYL)QUINAZOLINE-2,4(1H,3H)-DIONE AND 3-HYDROXY-PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE DERIVATIVES AND RELATED COMPOUNDS AS FLAP-ENDONUCLEASE 1 (FEN-1) INHIBITORS FOR USE IN CANCER THERAPY | LUDWIG INST FOR CANCER RES LTD (CH) | 2022-10-19 | — | — | EP | disclosed |