Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25871834 | 1.00 | SMN1; SMN2 (0.35) | SMN1; SMN2MEN1KMT2AMCL1MAPT | |
| SCHEMBL115839 | 1.00 | SMN1; SMN2 (0.35) | SMN1; SMN2MEN1KMT2AMCL1MAPT | |
| SCHEMBL29813282 | 0.91 | MEN1 (0.31) | MEN1KMT2AMAPT | |
| SCHEMBL14767358 | 0.88 | ALDH1A1 (0.39) | SMN1; SMN2MAPTALDH1A1L3MBTL1KDM4E | |
| SCHEMBL24809655 | 0.86 | TSHR (0.32) | MEN1KMT2AMAPT | |
| SCHEMBL23182669 | 0.85 | TSHR (0.31) | MEN1KMT2AMAPT | |
| SCHEMBL9999441 | 0.80 | LMNA (0.34) | SMN1; SMN2KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL9999181 | 0.80 | HTT (0.41) | SMN1; SMN2MAPTALDH1A1KDM4ENPC1 | |
| SCHEMBL5453679 | 0.77 | ALDH1A1 (0.39) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL23486175 | 0.75 | GABRA1 (0.37) | MEN1KMT2AALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115087647-A | Synthetic method for preparing 4- (2-chloro-4-methoxy-5-methylphenyl) -N- [ (1S) -2-cyclopropyl-1- (3-fluoro-4-methylphenyl) ethyl ] -5-methyl-N-prop-2-alkynyl-1, 3-thiazol-2-amine | 纽罗克里生物科学有限公司 | 2022-09-20 | — | — | CN | claimed |
| CN-114502162-B | CRF receptor antagonists and methods of use | 纽罗克里生物科学有限公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-118252829-A | CRF receptor antagonists and methods of use | 纽罗克里生物科学有限公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-116322668-A | Synthetic method for preparing 4- (2-chloro-4-methoxy-5-methylphenyl) -N- [ (1S) -2-cyclopropyl-1- (3-fluoro-4-methylphenyl) ethyl ] -5-methyl-N-prop-2-ynyl-1, 3-thiazol-2-amine | 纽罗克里生物科学有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-116096373-A | CRF1 receptor antagonists for the treatment of congenital adrenal hyperplasia | 纽罗克里生物科学有限公司 | 2023-05-09 | — | — | CN | disclosed |
| EP-4164636-A1 | CRF1 RECEPTOR ANTAGONIST FOR THE TREATMENT OF CONGENITAL ADRENAL HYPERPLASIA | Neurocrine Biosciences, Inc. (US) | 2023-04-19 | — | — | EP | disclosed |
| CN-115087647-A | Synthetic method for preparing 4- (2-chloro-4-methoxy-5-methylphenyl) -N- [ (1S) -2-cyclopropyl-1- (3-fluoro-4-methylphenyl) ethyl ] -5-methyl-N-prop-2-alkynyl-1, 3-thiazol-2-amine | 纽罗克里生物科学有限公司 | 2022-09-20 | — | — | CN | disclosed |