Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453679 | 0.87 | ALDH1A1 (0.39) | HTTSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL2107114 | 0.81 | HTT (0.47) | HTTSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL25845799 | 0.81 | LCK (0.46) | HTTSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL115839 | 0.80 | SMN1; SMN2 (0.35) | HTTSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL29936639 | 0.80 | SMN1; SMN2 (0.35) | HTTSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL23486043 | 0.80 | ALDH1A1 (0.33) | HTTSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL25871834 | 0.80 | SMN1; SMN2 (0.35) | HTTSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL17732591 | 0.77 | FFAR1 (0.41) | SMN1; SMN2KDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL5361341 | 0.77 | KDM4E (0.49) | HTTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL5643886 | 0.77 | HMGCR (0.51) | SMN1; SMN2KDM4ENPC1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240238257-A1 | SYNTHETIC METHODS FOR PREPARATION OF 4-(2-CHLORO-4-METHOXY-5-METHYLPHENYL)-N-[(1S)-2-CYCLOPROPYL-1-(3-FLUORO-4-METHYLPHENYL)ETHYL]-5-METHYL-N-PROP-2-YNYL-1,3-THIAZOL-2-AMINE | SANOFI (FR) | 2024-07-18 | — | — | US | disclosed |
| US-20230233534-A1 | SYNTHETIC METHODS FOR PREPARATION OF 4-(2-CHLORO-4-METHOXY-5-METHYLPHENYL)-N-[(1S)-2-CYCLOPROPYL-1-(3-FLUORO-4-METHYLPHENYL)ETHYL]-5-METHYL-N-PROP-2-YNYL-1,3-THIAZOL-2-AMINE | NEUROCRINE BIOSCIENCES, INC. | 2023-07-27 | — | — | US | disclosed |
| US-8314249-B2 | Process for the preparation of [4-(2-chloro-4-methoxy-5-methylphenyl)-5-methyl-thiazolo-2-yl]-[2-cyclopropyl-1-(3-fluoro-4-methylphenyl | SANOFI (FR) | 2012-11-20 | — | — | US | disclosed |
| US-20120083608-A1 | PROCESS FOR THE PREPARATION OF [4-(2-CHLORO-4- METHOXY-5-METHYLPHENYL)-5-METHYL-THIAZOLO-2-YL]-[2-CYCLOPROPYL-1-(3-FLUORO-4-METHYLPHENYL)-ETHYL]-AMINE | SANOFI (FR) | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083608-A1 | PROCESS FOR THE PREPARATION OF [4-(2-CHLORO-4- METHOXY-5-METHYLPHENYL)-5-METHYL-THIAZOLO-2-YL]-[2-CYCLOPROPYL-1-(3-FLUORO-4-METHYLPHENYL)-ETHYL]-AMINE | CYP4B1, CYP3A4, CYP4F2 | HTT 2742/4885SMN1; SMN2 1246/4885KDM4E 26/4885 |
| US-20230233534-A1 | SYNTHETIC METHODS FOR PREPARATION OF 4-(2-CHLORO-4-METHOXY-5-METHYLPHENYL)-N-[(1S)-2-CYCLOPROPYL-1-(3-FLUORO-4-METHYLPHENYL)ETHYL]-5-METHYL-N-PROP-2-YNYL-1,3-THIAZOL-2-AMINE | CYP21A2, NR5A1, HSD3B1 | HTT 2363/4885SMN1; SMN2 4376/4885KDM4E 914/4885 |
| US-20240238257-A1 | SYNTHETIC METHODS FOR PREPARATION OF 4-(2-CHLORO-4-METHOXY-5-METHYLPHENYL)-N-[(1S)-2-CYCLOPROPYL-1-(3-FLUORO-4-METHYLPHENYL)ETHYL]-5-METHYL-N-PROP-2-YNYL-1,3-THIAZOL-2-AMINE | CYP21A2, NR5A1, HSD3B1 | HTT 2212/4885SMN1; SMN2 4277/4885KDM4E 1158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.