Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.73 |
| ▸ | NPC1 | O15118 | 5/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.73 |
| ▸ | MEN1 | O00255 | 3/20 | 0.73 |
| ▸ | TP53 | P04637 | 3/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 7/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9495990 | 0.85 | MEN1 (0.59) | RAB9ASMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL7864765 | 0.84 | MEN1 (0.60) | RAB9ASMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL3455335 | 0.84 | RAB9A (1.00) | RAB9ASMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL9495976 | 0.84 | RAB9A (0.55) | RAB9ASMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL2534098 | 0.84 | L3MBTL1 (0.74) | RAB9ASMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL7873479 | 0.83 | MEN1 (0.59) | RAB9ASMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL8800416 | 0.82 | MEN1 (0.58) | RAB9ASMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL2536884 | 0.82 | L3MBTL1 (0.76) | RAB9ASMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL24627425 | 0.82 | MEN1 (0.60) | RAB9ASMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL18611678 | 0.81 | MGLL (0.59) | RAB9ASMN1; SMN2NPC1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230110003-A1 | PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | Valo Health, LLC | 2023-04-13 | — | — | US | disclosed |
| US-11479564-B2 | Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) | VALO HEALTH, INC. (US) | 2022-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230110003-A1 | PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | NAMPT, NAPRT, NNMT | RAB9A 2108/4885SMN1; SMN2 2010/4885NPC1 322/4885 |
| US-11479564-B2 | Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) | NAMPT, NAPRT, NNMT | RAB9A 2108/4885SMN1; SMN2 2010/4885NPC1 322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.