Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | SIGLEC9 | Q9Y336 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3454926 | 1.00 | ALDH1A1 (0.59) | ALDH1A1HPGDHTR2CSIGLEC9KDM4E | |
| SCHEMBL13779957 | 0.85 | HTR2C (0.55) | ALDH1A1HPGDHTR2CSIGLEC9KDM4E | |
| SCHEMBL3589409 | 0.83 | ALDH1A1 (0.61) | ALDH1A1HPGDHTR2CKDM4EMEN1 | |
| SCHEMBL3402654 | 0.81 | SIGLEC9 (0.48) | ALDH1A1HPGDHTR2CSIGLEC9MEN1 | |
| SCHEMBL3589407 | 0.81 | ALDH1A1 (0.54) | ALDH1A1HPGDHTR2CKDM4EMEN1 | |
| SCHEMBL1426839 | 0.79 | ALDH1A1 (0.52) | ALDH1A1HPGDHTR2CSIGLEC9KDM4E | |
| SCHEMBL3402162 | 0.78 | ALDH1A1 (0.46) | ALDH1A1HPGDHTR2CSIGLEC9MEN1 | |
| SCHEMBL5776775 | 0.77 | ALDH1A1 (0.38) | ALDH1A1HPGDHTR2CSIGLEC9MEN1 | |
| SCHEMBL3454733 | 0.77 | SIGLEC9 (0.47) | ALDH1A1HPGDHTR2CSIGLEC9MEN1 | |
| SCHEMBL12789540 | 0.76 | CNR1 (0.77) | ALDH1A1HPGDHTR2CKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230110003-A1 | PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | Valo Health, LLC | 2023-04-13 | — | — | US | disclosed |
| US-11479564-B2 | Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) | VALO HEALTH, INC. (US) | 2022-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230110003-A1 | PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | NAMPT, NAPRT, NNMT | ALDH1A1 265/4885HPGD 105/4885HTR2C 3428/4885 |
| US-11479564-B2 | Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) | NAMPT, NAPRT, NNMT | ALDH1A1 265/4885HPGD 105/4885HTR2C 3428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.