Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 17/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10113271 | 0.82 | HSD17B10 (0.74) | ADORA2BMAPK1ADORA2AHSD17B10 | |
| SCHEMBL10113267 | 0.81 | HSD17B10 (0.72) | ADORA2BMAPK1ADORA2AHSD17B10 | |
| SCHEMBL2999682 | 0.77 | ADORA2B (0.69) | ADORA2BMAPK1ADORA2AHSD17B10 | |
| SCHEMBL4083873 | 0.76 | ADORA2B (0.62) | ADORA2BMAPK1ADORA2AHSD17B10 | |
| SCHEMBL10113258 | 0.75 | TSHR (0.75) | ADORA2BMAPK1CYP2C9CYP2C19ADORA2A | |
| SCHEMBL3005564 | 0.75 | PKM (0.75) | ADORA2BMAPK1ADORA2AHSD17B10 | |
| SCHEMBL10113282 | 0.74 | MAPK1 (0.76) | ADORA2BMAPK1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4253445 | 0.74 | ADORA2B (0.59) | ADORA2BMAPK1ADORA2AHSD17B10 | |
| SCHEMBL19752713 | 0.73 | MEN1 (0.67) | ADORA2BCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL19752712 | 0.73 | MEN1 (0.67) | ADORA2BCYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045428-B2 | Substituted heterocyclic compounds | GILEAD SCIENCES, INC. (US) | 2015-06-02 | — | — | US | disclosed |
| US-8716319-B2 | Substituted heterocyclic compounds | GILEAD SCIENCES, INC. (US) | 2014-05-06 | — | — | US | disclosed |
| US-20130324525-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2013-12-05 | — | — | US | disclosed |
| US-20100197684-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | GILEAD PALO ALTO, INC. (US) | 2010-08-05 | — | — | US | disclosed |
| US-20090012103-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. | 2009-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197684-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | NQO1, GPR119, GLP1R | ADORA2B 713/4885MAPK1 1673/4885CYP1A2 74/4885 |
| US-20130324525-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | NQO1, GPR119, GLP1R | ADORA2B 713/4885MAPK1 1673/4885CYP1A2 74/4885 |
| US-20090012103-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | NQO1, GPR119, GLP1R | ADORA2B 713/4885MAPK1 1673/4885CYP1A2 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.