Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 6/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | JAK1 | P23458 | 3/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29944809 | 0.92 | ENPP2 (0.37) | ENPP2USP30MEN1KMT2ANPSR1 | |
| SCHEMBL29944802 | 0.83 | JAK3 (0.56) | JAK3 | |
| SCHEMBL30305650 | 0.76 | JAK3 (0.49) | ENPP2JAK3 | |
| SCHEMBL22609913 | 0.76 | JAK3 (0.49) | ENPP2JAK3 | |
| SCHEMBL29944949 | 0.76 | JAK3 (0.55) | JAK3 | |
| SCHEMBL18838495 | 0.71 | ENPP2 (0.44) | ENPP2USP30OPRK1SMN1; SMN2NPC1 | |
| SCHEMBL29944811 | 0.69 | SMN1; SMN2 (0.54) | ENPP2MEN1KMT2ANPSR1OPRK1 | |
| SCHEMBL22609916 | 0.68 | BTK (0.38) | JAK3 | |
| SCHEMBL29944821 | 0.68 | SMN1; SMN2 (0.43) | MEN1KMT2ANPSR1OPRK1SMN1; SMN2 | |
| SCHEMBL22469324 | 0.68 | CTSL (0.48) | USP30MEN1KMT2ANPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115244055-B | Pyrimidine five-membered ring derivative and application thereof | 江苏先声药业有限公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-115244055-A | Pyrimido five-membered ring derivative and application thereof | 江苏先声药业有限公司 | 2022-10-25 | — | — | CN | disclosed |