Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17479489 | 0.85 | ALB (0.45) | TSHRSMN1; SMN2KDM4ERAB9ANPC1 | |
| SCHEMBL31438554 | 0.82 | TSHR (0.46) | TSHRSMN1; SMN2KDM4ETDP1TP53 | |
| SCHEMBL17479507 | 0.82 | TSHR (0.46) | TSHRSMN1; SMN2KDM4ETDP1TP53 | |
| SCHEMBL621753 | 0.80 | CA12 (0.53) | TSHRKDM4ERAB9APOLBCA12 | |
| SCHEMBL30432593 | 0.80 | CA12 (0.53) | TSHRKDM4ERAB9APOLBCA12 | |
| SCHEMBL4625647 | 0.79 | TSHR (0.61) | TSHRSMN1; SMN2KDM4ERAB9ANPC1 | |
| SCHEMBL23526377 | 0.78 | ALOX5 (0.40) | TSHRKDM4ETP53KMT2A | |
| SCHEMBL29945784 | 0.78 | ALOX5 (0.40) | TSHRKDM4ETP53KMT2A | |
| SCHEMBL1586012 | 0.77 | KMT2A (0.47) | TSHRKDM4EPOLBCA12CA1 | |
| SCHEMBL11296630 | 0.77 | TSHR (0.63) | TSHRSMN1; SMN2KDM4ETDP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180317-B1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME (US) | 2021-04-14 | — | — | EP | disclosed |
| US-9868727-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-01-16 | — | — | US | disclosed |
| US-20170210732-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170210732-A1 | Factor XIa Inhibitors | F11, SERPINC1, TFPI | TSHR 3448/4885SMN1; SMN2 4591/4885KDM4E 454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.