Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 5/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HEXA | P06865 | 4/20 | 0.37 |
| ▸ | HEXB | P07686 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23534954 | 1.00 | NUDT1 (0.41) | NUDT1DHFRGRM4HSP90AA1HEXA | |
| SCHEMBL27559232 | 0.79 | GRM4 (0.39) | NUDT1GRM4HSP90AA1 | |
| SCHEMBL22834670 | 0.79 | LMNA (0.40) | NUDT1GRM4HSP90AA1MEN1LMNA | |
| SCHEMBL29652037 | 0.79 | LMNA (0.40) | NUDT1GRM4HSP90AA1MEN1LMNA | |
| SCHEMBL10399566 | 0.78 | NUDT1 (0.43) | NUDT1DHFRHSP90AA1HEXAHEXB | |
| SCHEMBL27559431 | 0.78 | NUDT1 (0.40) | NUDT1GRM4HSP90AA1 | |
| SCHEMBL18031204 | 0.77 | NUDT1 (0.59) | NUDT1GRM4HSP90AA1HEXAHEXB | |
| SCHEMBL28150953 | 0.77 | DHFR (0.49) | NUDT1DHFRHSP90AA1 | |
| SCHEMBL232075 | 0.75 | NUDT1 (0.41) | NUDT1DHFRHSP90AA1HEXAHEXB | |
| SCHEMBL233104 | 0.75 | NUDT1 (0.42) | NUDT1DHFRGRM4HSP90AA1HEXA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4077282-A1 | PRMT5 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2022-10-26 | — | — | EP | disclosed |
| EP-4076459-A1 | PRMT5 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2022-10-26 | — | — | EP | disclosed |