Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 2/20 | 0.33 |
| ▸ | EDNRA | P25101 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536496 | 0.86 | ALDH1A1 (0.34) | ALDH1A1TDP1 | |
| SCHEMBL17493468 | 0.74 | CA2 (0.43) | HTTCA2PLCG1TDP1MAPT | |
| SCHEMBL17493444 | 0.68 | F2 (0.36) | ALDH1A1CA2PLCG1TDP1MAPT | |
| SCHEMBL20692191 | 0.67 | SMYD3 (0.32) | ALDH1A1 | |
| SCHEMBL20698717 | 0.67 | SMYD3 (0.32) | ALDH1A1CA2CA12CA1LMNA | |
| SCHEMBL21962416 | 0.67 | APLNR (0.47) | CA2CYP3A4CYP2C9CYP2C19CA12 | |
| SCHEMBL116525 | 0.66 | LMNA (0.59) | ALDH1A1HTTCA2PLCG1MAPT | |
| SCHEMBL20692237 | 0.64 | — | — | |
| SCHEMBL25389836 | 0.64 | EDNRB (0.39) | ALDH1A1CA2TDP1F2PRSS1 | |
| SCHEMBL30562597 | 0.64 | EDNRB (0.39) | ALDH1A1CA2TDP1F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |