Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6074155 | 1.00 | SMN1; SMN2 (0.57) | SMN1; SMN2GAAALDH1A1KMT2AMEN1 | |
| SCHEMBL4555801 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2GAAALDH1A1KMT2AMEN1 | |
| SCHEMBL1274938 | 0.81 | HTT (0.73) | SMN1; SMN2GAAALDH1A1KMT2AMEN1 | |
| SCHEMBL5095834 | 0.80 | HTT (0.56) | SMN1; SMN2GAAALDH1A1KMT2AMEN1 | |
| SCHEMBL30779614 | 0.80 | CTSB (0.68) | SMN1; SMN2ALDH1A1KMT2AMEN1HTT | |
| SCHEMBL2206983 | 0.80 | CTSB (0.68) | SMN1; SMN2ALDH1A1KMT2AMEN1HTT | |
| SCHEMBL23043706 | 0.79 | HTR1A (0.60) | SMN1; SMN2GAAALDH1A1KMT2AHTT | |
| SCHEMBL3799173 | 0.77 | CTSB (0.65) | SMN1; SMN2GAAALDH1A1KMT2AHTT | |
| SCHEMBL29937743 | 0.77 | CTSB (0.65) | SMN1; SMN2GAAALDH1A1KMT2AHTT | |
| SCHEMBL7118705 | 0.77 | HTT (0.64) | SMN1; SMN2GAAALDH1A1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |