Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 8/20 | 0.60 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.49 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1020883 | 1.00 | TRPV4 (0.60) | TRPV4HSD11B1VCAM1SLC22A12FLT1 | |
| SCHEMBL7532971 | 0.92 | TRPV4 (0.53) | TRPV4HSD11B1VCAM1FLT1FLT4 | |
| SCHEMBL1942524 | 0.85 | TRPV4 (0.56) | TRPV4HSD11B1VCAM1SLC22A12FLT1 | |
| SCHEMBL31461007 | 0.85 | TRPV4 (0.56) | TRPV4HSD11B1VCAM1SLC22A12FLT1 | |
| SCHEMBL11871395 | 0.83 | HSD11B1 (0.51) | TRPV4HSD11B1VCAM1SLC22A12FLT1 | |
| SCHEMBL20744421 | 0.83 | PTGES2 (0.50) | TRPV4HSD11B1VCAM1SLC22A12FLT1 | |
| SCHEMBL12560661 | 0.83 | HSD11B1 (0.51) | TRPV4HSD11B1VCAM1SLC22A12FLT1 | |
| Hydrochloric Acid SCHEMBL5097125 | 0.81 | HSD11B1 (0.50) | TRPV4HSD11B1VCAM1SLC22A12FLT1 | |
| SCHEMBL13277732 | 0.81 | HSD11B1 (0.50) | TRPV4HSD11B1VCAM1SLC22A12FLT1 | |
| SCHEMBL13277731 | 0.81 | RAD51 (0.58) | TRPV4HSD11B1VCAM1SLC22A12FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4061124-A1 | TRPV4 RECEPTOR LIGANDS | University of Utah Research Foundation (US) | 2022-09-28 | — | — | EP | disclosed |