Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 11/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1020883 | 0.92 | TRPV4 (0.60) | TRPV4HSD11B1FLT1FLT4KDR | |
| SCHEMBL29948706 | 0.92 | TRPV4 (0.60) | TRPV4HSD11B1FLT1FLT4KDR | |
| SCHEMBL61854 | 0.82 | CA1 (0.55) | TRPV4CA12CA1CA2CA9 | |
| SCHEMBL13277731 | 0.78 | RAD51 (0.58) | TRPV4HSD11B1FLT1FLT4KDR | |
| SCHEMBL1942524 | 0.78 | TRPV4 (0.56) | TRPV4HSD11B1FLT1FLT4KDR | |
| SCHEMBL31461007 | 0.78 | TRPV4 (0.56) | TRPV4HSD11B1FLT1FLT4KDR | |
| SCHEMBL4377093 | 0.77 | CA12 (0.66) | HSD11B1CA12CA1CA2CA9 | |
| SCHEMBL11427098 | 0.77 | TRPV4 (0.55) | TRPV4HSD11B1CA12CA1CA2 | |
| SCHEMBL20744421 | 0.76 | PTGES2 (0.50) | TRPV4HSD11B1FLT1FLT4KDR | |
| SCHEMBL11871395 | 0.76 | HSD11B1 (0.51) | TRPV4HSD11B1FLT1FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002028353-A2 | PHOSPHATE TRANSPORT INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-11 | — | — | WO | disclosed |