SCHEMBL29948709

SCHEMBL29948709

COC(=O)c1ccc(S(=O)(=O)Cl)c(Cl)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.54
SMN1; SMN2 Q16637 3/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
CYP1A2 P05177 1/20 0.54
TSHR P16473 1/20 0.54
CYP2C19 P33261 1/20 0.54
VCAM1 P19320 1/20 0.49
PDK1 Q15118 2/20 0.48
PDK2 Q15119 2/20 0.48
PDK3 Q15120 2/20 0.48
PDK4 Q16654 2/20 0.48
KDM4E B2RXH2 4/20 0.48
HPGD P15428 3/20 0.48
GAA P10253 2/20 0.48
PKM P14618 1/20 0.48
CA12 O43570 2/20 0.47
CA1 P00915 2/20 0.47
CA2 P00918 2/20 0.47
CA7 P43166 2/20 0.47
CA9 Q16790 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3164592 1.00 ALDH1A1 (0.54) ALDH1A1SMN1; SMN2L3MBTL1CYP1A2TSHR
SCHEMBL1495720 0.87 ALDH1A1 (0.65) ALDH1A1SMN1; SMN2L3MBTL1CYP1A2TSHR
SCHEMBL6970979 0.83 VCAM1 (0.49) ALDH1A1SMN1; SMN2L3MBTL1CYP1A2TSHR
SCHEMBL9324149 0.83 KDM4E (0.53) ALDH1A1SMN1; SMN2L3MBTL1CYP1A2TSHR
SCHEMBL120300 0.83 ALDH1A1 (0.56) ALDH1A1L3MBTL1CYP1A2KDM4EHPGD
SCHEMBL20488862 0.83 TSHR (0.57) ALDH1A1SMN1; SMN2L3MBTL1CYP1A2TSHR
SCHEMBL30545664 0.82 TRPV4 (0.58) ALDH1A1SMN1; SMN2L3MBTL1CYP1A2TSHR
SCHEMBL9093802 0.82 TRPV4 (0.58) ALDH1A1SMN1; SMN2L3MBTL1CYP1A2TSHR
SCHEMBL3118833 0.82 ACLY (0.48) ALDH1A1SMN1; SMN2L3MBTL1CYP1A2TSHR
SCHEMBL31587402 0.80 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2L3MBTL1CYP1A2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4061124-A1 TRPV4 RECEPTOR LIGANDS University of Utah Research Foundation (US) 2022-09-28 EP disclosed