Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 4/20 | 0.47 |
| ▸ | TYR | P14679 | 2/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.47 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.41 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.41 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29951666 | 0.86 | ERN1 (0.54) | PLK1HDAC6HDAC8HDAC2THRB | |
| SCHEMBL24070571 | 0.85 | PLK1 (0.50) | PLK1HDAC6HDAC8HDAC2THRB | |
| SCHEMBL29957809 | 0.83 | ERN1 (0.59) | HDAC6HDAC8ERN1CDK8 | |
| SCHEMBL15920688 | 0.82 | PLK1 (0.47) | PLK1HDAC6HDAC8HDAC2THRB | |
| SCHEMBL31166972 | 0.81 | ERN1 (0.60) | TYRTRIM24TRIM33HPGDERN1 | |
| SCHEMBL20017813 | 0.81 | PLK1 (0.46) | PLK1HDAC6HDAC8HDAC2THRB | |
| SCHEMBL11585526 | 0.79 | TYR (0.52) | TYRTRIM24TRIM33HTTERN1 | |
| SCHEMBL328702 | 0.79 | HDAC6 (0.67) | HDAC6HDAC8HDAC2THRBPLAU | |
| SCHEMBL12132593 | 0.79 | PLAU (0.47) | PLK1HDAC6HDAC8HDAC2THRB | |
| SCHEMBL1485297 | 0.79 | XDH (0.65) | TYRTRIM24TRIM33SMN1; SMN2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |