Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | PKLR | P30613 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | SI | P14410 | 4/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | BRD1 | O95696 | 1/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1893764 | 1.00 | NPC1 (0.44) | NPC1MAPTRAB9ACOXFA4PKM | |
| SCHEMBL1371172 | 0.83 | MAPT (0.41) | MAPTGAASTS | |
| SCHEMBL3184205 | 0.78 | AKT1 (0.56) | NPC1MAPTRAB9ACOXFA4PKM | |
| SCHEMBL30513267 | 0.78 | AKT1 (0.56) | NPC1MAPTRAB9ACOXFA4PKM | |
| SCHEMBL7931244 | 0.77 | MAPT (0.43) | NPC1MAPTRAB9ACOXFA4PKM | |
| SCHEMBL6849624 | 0.76 | PKM (0.49) | NPC1MAPTRAB9ACOXFA4PKM | |
| SCHEMBL639690 | 0.75 | PKM (0.58) | NPC1MAPTRAB9APKMPDE10A | |
| SCHEMBL30511906 | 0.75 | PKM (0.58) | NPC1MAPTRAB9APKMPDE10A | |
| SCHEMBL3042985 | 0.75 | MAPT (0.47) | NPC1MAPTRAB9ACOXFA4PKM | |
| SCHEMBL6025550 | 0.75 | PKM (0.48) | NPC1MAPTRAB9ACOXFA4PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |