Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.43 |
| ▸ | DAGLA | Q9Y4D2 | 5/20 | 0.43 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.43 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PKLR | P30613 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | BRD1 | O95696 | 1/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972444 | 0.88 | MAPT (0.45) | MAPTPLCG2DAGLAABHD6COXFA4 | |
| SCHEMBL21950002 | 0.81 | MAPT (0.55) | MAPTPLCG2DAGLAABHD6COXFA4 | |
| SCHEMBL4017321 | 0.80 | MAPT (0.46) | MAPTPLCG2DAGLAABHD6COXFA4 | |
| SCHEMBL16082385 | 0.78 | SCN9A (0.45) | MAPTPLCG2DAGLAABHD6COXFA4 | |
| SCHEMBL29952832 | 0.77 | NPC1 (0.44) | MAPTDAGLACOXFA4PKMNPC1 | |
| SCHEMBL1893764 | 0.77 | NPC1 (0.44) | MAPTDAGLACOXFA4PKMNPC1 | |
| SCHEMBL8894557 | 0.74 | MAPT (0.47) | MAPTPLCG2DAGLACOXFA4PKM | |
| SCHEMBL30513267 | 0.74 | AKT1 (0.56) | MAPTCOXFA4PKMNPC1RAB9A | |
| SCHEMBL669764 | 0.74 | MAPT (0.47) | MAPTPLCG2DAGLACOXFA4PKM | |
| SCHEMBL3184205 | 0.74 | AKT1 (0.56) | MAPTCOXFA4PKMNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140896-A1 | BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 | Takeda Chemical Industries, Ltd. (JP) | 2001-10-10 | — | — | EP | disclosed |
| US-6235771-B1 | AIDS THERPAY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| WO-2000037455-A1 | BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-06-29 | — | — | WO | disclosed |