Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MDM4 | O15151 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27033790 | 1.00 | AKR1C3 (0.50) | AKR1C3MAOBKDM4EALDH1A1KMT2A | |
| SCHEMBL28595702 | 0.84 | AKR1C3 (0.48) | AKR1C3MAOBKDM4EALDH1A1KMT2A | |
| SCHEMBL29289244 | 0.81 | ALDH1A1 (0.65) | AKR1C3KDM4EALDH1A1KMT2APOLB | |
| SCHEMBL29289242 | 0.81 | ALDH1A1 (0.65) | AKR1C3KDM4EALDH1A1KMT2APOLB | |
| SCHEMBL29178129 | 0.72 | NFE2L2 (0.61) | MAOBCYP1A2CYP2C9NFE2L2 | |
| SCHEMBL29178131 | 0.72 | NFE2L2 (0.61) | MAOBCYP1A2CYP2C9NFE2L2 | |
| SCHEMBL6333516 | 0.72 | FBP1 (0.54) | AKR1C3MAOBKDM4EALDH1A1KMT2A | |
| SCHEMBL6333513 | 0.72 | FBP1 (0.54) | AKR1C3MAOBKDM4EALDH1A1KMT2A | |
| SCHEMBL28210065 | 0.71 | TSHR (0.70) | KDM4EALDH1A1KMT2APOLBFBP1 | |
| SCHEMBL10731566 | 0.71 | PGR (0.41) | ALDH1A1KMT2AFBP1PGRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308228-A1 | PLASMA KALLIKREIN INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| CN-117396474-A | Plasma kallikrein inhibitors | 武田药品工业株式会社 | 2024-01-12 | — | — | CN | disclosed |
| WO-2022197756-A1 | PLASMA KALLIKREIN INHIBITORS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |