Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234356 | 1.00 | CYP1A2 (0.47) | CYP1A2LOXL2PDE4ATHRBTGFBR1 | |
| SCHEMBL5237932 | 0.90 | CYP1A2 (0.48) | CYP1A2LOXL2PDE4AADORA2AADORA1 | |
| SCHEMBL5267623 | 0.84 | MRGPRX4 (0.37) | CYP1A2 | |
| SCHEMBL5235225 | 0.84 | CYP1A2 (0.49) | CYP1A2LOXL2PDE4ATGFBR1MAPK14 | |
| SCHEMBL29959459 | 0.84 | CYP1A2 (0.49) | CYP1A2LOXL2PDE4ATGFBR1MAPK14 | |
| SCHEMBL5233274 | 0.84 | CYP1A2 (0.55) | CYP1A2LOXL2PDE4AADORA2AADORA1 | |
| SCHEMBL5236988 | 0.82 | CYP1A2 (0.49) | CYP1A2LOXL2PDE4AADORA2AADORA1 | |
| SCHEMBL5236887 | 0.82 | CYP1A2 (0.49) | CYP1A2LOXL2PDE4ATGFBR1MAPK14 | |
| SCHEMBL4872415 | 0.82 | CYP1A2 (0.49) | CYP1A2LOXL2PDE4ATGFBR1ADORA2A | |
| SCHEMBL5235242 | 0.81 | CYP1A2 (0.46) | CYP1A2LOXL2PDE4ATHRBTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250333395-A1 | BENZYLAMIDE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR I/ALK5 | Agomab Spain, S.L.U. (ES) | 2025-10-30 | — | — | US | disclosed |
| CN-114787145-B | Benzamide derivatives as transforming growth factor-beta receptor I/ALK5 inhibitors | 阿戈麦布西班牙股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| EP-4065572-A1 | BENZYLAMIDE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR I/ALK5 | Origo Biopharma, S.L. (ES) | 2022-10-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250333395-A1 | BENZYLAMIDE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR I/ALK5 | TGFBR2, TGFBR1, ACVR1 | CYP1A2 3030/4885LOXL2 201/4885PDE4A 2393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.