Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 9/20 | 0.35 |
| ▸ | CBLB | Q13191 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29959944 | 0.84 | CYP1A2 (0.47) | CYP1A2 | |
| SCHEMBL5234356 | 0.84 | CYP1A2 (0.47) | CYP1A2 | |
| SCHEMBL5237932 | 0.75 | CYP1A2 (0.48) | CYP1A2KDM4E | |
| SCHEMBL5231489 | 0.74 | PRNP (0.45) | MRGPRX4CYP1A2KDM4ECLK1 | |
| SCHEMBL5234890 | 0.72 | P2RX7 (0.39) | CYP1A2KDM4E | |
| SCHEMBL4872415 | 0.72 | CYP1A2 (0.49) | CYP1A2KDM4EMAPTCLK1 | |
| SCHEMBL5231308 | 0.70 | SRC (0.42) | — | |
| SCHEMBL5231071 | 0.70 | MEN1 (0.36) | PTGER1CYP1A2CYP2C9MAPT | |
| SCHEMBL6671176 | 0.70 | NPC1 (0.40) | — | |
| SCHEMBL4490632 | 0.70 | P2RX7 (0.39) | CYP1A2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |