Sugi Predict

Sugi Predict / Compounds / SCHEMBL299601

SCHEMBL299601

SCHEMBL299601

Nc1c(Cl)cc(C(F)(C(F)(F)F)C(F)(F)F)cc1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.46
▸ CYP3A4 P08684 3/20 0.46
▸ KDM4E B2RXH2 2/20 0.38
▸ POLB P06746 1/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ CA1 P00915 2/20 0.37
▸ CA2 P00918 2/20 0.37
▸ CA9 Q16790 2/20 0.37
▸ PLAU P00749 1/20 0.34
▸ CYP1A2 P05177 1/20 0.33
▸ CYP2C19 P33261 1/20 0.33
▸ GAA P10253 2/20 0.32
▸ MRGPRX4 Q96LA9 1/20 0.32
▸ LMNA P02545 2/20 0.31
▸ TSHR P16473 2/20 0.31
▸ ADRB2 P07550 1/20 0.31
▸ ADRB1 P08588 1/20 0.31
▸ HTR1A P08908 1/20 0.31
▸ SLC6A2 P23975 1/20 0.31
▸ SLC6A4 P31645 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL289962 0.89 ALDH1A1 (0.41) ALDH1A1CYP3A4KDM4EPOLBSMN1; SMN2
SCHEMBL13516413 0.89 ALDH1A1 (0.41) ALDH1A1CYP3A4KDM4EPOLBSMN1; SMN2
SCHEMBL16150965 0.87 POLB (0.39) ALDH1A1CYP3A4KDM4EPOLBSMN1; SMN2
SCHEMBL289233 0.86 CA1 (0.43) ALDH1A1CYP3A4KDM4EPOLBSMN1; SMN2
SCHEMBL1767131 0.86 ADRB2 (0.40) ALDH1A1CYP3A4KDM4EPOLBSMN1; SMN2
SCHEMBL18726210 0.82 ALDH1A1 (0.32) ALDH1A1CYP3A4KDM4EPOLBSMN1; SMN2
SCHEMBL16150579 0.81 AR (0.34) ALDH1A1CYP3A4KDM4EPOLBSMN1; SMN2
SCHEMBL4603768 0.81 ALDH1A1 (0.31) ALDH1A1CYP3A4KDM4EPOLBSMN1; SMN2
SCHEMBL4183063 0.81 CYP3A4 (0.33) ALDH1A1CYP3A4KDM4EPOLBSMN1; SMN2
SCHEMBL10725590 0.81 ALDH1A1 (0.46) ALDH1A1CYP3A4KDM4EPOLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115894442-B Substituted benzamide derivative or salt and composition acceptable by pesticides and application thereof 海利尔药业集团股份有限公司 2025-02-14 — — CN disclosed
CN-118221639-A N-substituted phenylpyrazole derivative and preparation and application thereof 顺毅股份有限公司 2024-06-21 — — CN disclosed
CN-117736196-A Pyridine amide derivative and application thereof 顺毅股份有限公司 2024-03-22 — — CN disclosed
US-20230148600-A1 PESTICIDALLY ACTIVE THIOPHENE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2023-05-18 — — US disclosed
US-20230148600-A1 PESTICIDALLY ACTIVE THIOPHENE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2023-05-18 — — US disclosed
CN-115894442-A Substituted benzamide derivative or salt acceptable as pesticide, composition and application thereof 海利尔药业集团股份有限公司 2023-04-04 — — CN disclosed
US-11490620-B2 Pesticidally active thiophene derivatives SYNGENTA PARTICIPATIONS AG (SE) 2022-11-08 — — US disclosed
US-20220048847-A1 PROCESS FOR PREPARING SUBSTITUTED ANILINES BAYER AKTIENGESELLSCHAFT (DE) 2022-02-17 — — US disclosed
CN-106242998-B Use of 4-cyano-3-benzoylamino-N-phenyl-benzamides in pesticides 先正达参股股份有限公司 2021-11-05 — — CN disclosed
EP-3898574-A1 PROCESS FOR PREPARING SUBSTITUTED ANILINES Bayer Aktiengesellschaft (DE) 2021-10-27 — — EP disclosed
EP-1893581-A1 SUBSTITUTED ARYLPYRAZOLES FOR USE AGAINST PARASITITES Pfizer Limited (GB) 2008-03-05 — — EP disclosed
US-20060287365-A1 Substituted arylpyrazoles ZOETIS LLC 2006-12-21 — — US disclosed
WO-2006134468-A1 SUBSTITUTED ARYLPYRAZOLES FOR USE AGAINST PARASITITES PFIZER LIMITED (GB) 2006-12-21 — — WO disclosed
EP-1006102-B1 Process for the production of perfluoroalkylated aniline derivatives NIHON NOHYAKU CO LTD (JP) 2006-08-30 — — EP disclosed
US-6717013-B2 EASILY ATTAINED WITH HIGH POSITIONAL SELECTIVITY AND YIELD; INTERMEDIATES AND RAW MATERIALS NIHON NOHYAKU CO., LTD. (JP) 2004-04-06 — — US disclosed
EP-1380568-A2 Perfluoroalkylaniline derivatives NIHON NOHYAKU CO., LTD. (JP) 2004-01-14 — — EP disclosed
US-20030204104-A1 Perfluoroalkylated aniline compound and process for producing the same NIHON NOHYAKU CO., LTD. (JP) 2003-10-30 — — US disclosed
US-6600074-B2 Useful as intermediates or raw materials for the synthesis of agricultural chemicals, pharmaceuticals NIHON NOHYAKU CO., LTD. (JP) 2003-07-29 — — US disclosed
US-20020198399-A1 Perfluoroalkylated aniline compound and process for producing the same NIHON NOHYAKU CO., LTD. (JP) 2002-12-26 — — US disclosed
EP-1006102-A2 Aniline derivative and process for producing the same NIHON NOHYAKU CO., LTD. (JP) 2000-06-07 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060287365-A1 Substituted arylpyrazoles CYP3A4, CYP3A43, CYP4B1 ALDH1A1 565/4885CYP3A4 1/4885KDM4E 942/4885
US-20220048847-A1 PROCESS FOR PREPARING SUBSTITUTED ANILINES CYP1A2, CYP1A1, CYP1B1 ALDH1A1 143/4885CYP3A4 4/4885KDM4E 1304/4885
US-11490620-B2 Pesticidally active thiophene derivatives ACHE, DDT, GSTP1 ALDH1A1 522/4885CYP3A4 825/4885KDM4E 1156/4885
US-20230148600-A1 PESTICIDALLY ACTIVE THIOPHENE DERIVATIVES ACHE, DDT, GSTP1 ALDH1A1 444/4885CYP3A4 804/4885KDM4E 1206/4885
US-20020198399-A1 Perfluoroalkylated aniline compound and process for producing the same CYP8B1, CCR8, AFF1 ALDH1A1 722/4885CYP3A4 107/4885KDM4E 2319/4885
US-20030204104-A1 Perfluoroalkylated aniline compound and process for producing the same CYP8B1, CCR8, AFF1 ALDH1A1 722/4885CYP3A4 107/4885KDM4E 2319/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.